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Article Dans Une Revue Tetrahedron Année : 2017

Adamantyl aziridines via aza-Michael initiated ring closure (aza-MIRC) reaction

Résumé

An efficient one-pot synthesis of functionalized adamantylaziridines by aza-Michael initiated ring closure (aza-MIRC) reaction of 1-aminoadamantane with α-halogenated Michael acceptors is described. The reaction goes through an aza-Michael intermediate that undergoes an intramolecular nucleophilic substitution. Expectedly, high pressure exerts a beneficial influence in the case of sterically hindered reagents.

Domaines

Chimie organique
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Dates et versions

hal-02019165 , version 1 (14-02-2019)

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Citer

Alena Fedotova, Tatiana Komarova, Alexey Romanov, Igor Ushakov, Julien Legros, et al.. Adamantyl aziridines via aza-Michael initiated ring closure (aza-MIRC) reaction. Tetrahedron, 2017, 73 (8), pp.1120-1126. ⟨10.1016/j.tet.2017.01.006⟩. ⟨hal-02019165⟩
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