Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation - Archive ouverte HAL Access content directly
Journal Articles Journal of Biological Chemistry Year : 2012

Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

Abstract

Background: Galectin-1 (GAL1) is a ligand for the pre-BCR which is involved in the proliferation and differentiation of normal pre-BII cells. Results: GAL1-dependent pre-BCR clustering is driven mainly by hydrophobic contacts. Conclusion: Constitutive and ligand-induced pre-BCR activation can occur in a complementary manner. Significance: This is the first molecular snapshot of a pre-BCR/ligand interaction that helps pre-BCR clustering and activation.
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hal-02018151 , version 1 (13-02-2019)

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Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, et al.. Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation. Journal of Biological Chemistry, 2012, 287 (53), pp.44703-44713. ⟨10.1074/jbc.m112.395152⟩. ⟨hal-02018151⟩
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