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Article Dans Une Revue Journal of the Acoustical Society of America Année : 2018

Nonlinear ultrasound parameter to monitor cell death in cancer cell samples

Résumé

A scaling subtraction method was proposed to analyze the radio frequency data from cancer cell samples exposed to an anti-cancer drug and to estimate a nonlinear parameter. The nonlinear parameter was found to be well correlated (R2=0.62) to the percentage of dead cells in apoptosis and necrosis. The origin of the nonlinearity may be related to a change in contacts between cells, since the nonlinear parameter was well correlated to the average total coordination number of binary packings (R2>0.77). These results suggest that the scaling subtraction method may be used to early quantify chemotherapeutic treatment efficiency.
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Dates et versions

hal-02016703 , version 1 (12-02-2019)

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Pauline Muleki-Seya, Cedric Payan, Laure Balasse, Régine Guillermin, Sandrine Roffino, et al.. Nonlinear ultrasound parameter to monitor cell death in cancer cell samples. Journal of the Acoustical Society of America, 2018, 144 (5), pp.EL374-EL379. ⟨10.1121/1.5066348⟩. ⟨hal-02016703⟩
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