Force-induced repolarization of an active crawler
Résumé
We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a selfconsistent mechanical explanation for all experimentally observed outcomes of cell collision tests.
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