By the combination of suitable catalytic methodologies, the synthesis of complex molecules could be performed with limited footprints and energy consumption either in orthogonal multicatalysis, sequential one-pot reactions or sequential reactions in continuous flow. In this account, we present a selection of our recent results in this area of research where several catalysts such as supported metal nanoparticles, supported metal salts, or mineral and organic bases were combined. New and step-economical synthetic methods were thus developed either in standard batch reactors or in continuous flow using millifluidic technology.