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Article Dans Une Revue Physical Review Letters Année : 2012

Transport of Long Neutral Polymers in the Semidilute Regime through a Protein Nanopore

Résumé

We investigate the entrance of single poly(ethylene glycol) (PEG) chains into an α-Hemolysin channel. We detect the frequency and duration of the current blockades induced by large neutral polymers, where chain radius is larger than pore diameter. In the semi-dilute regime, these chains pass only if the monomer concentration is larger than a well-defined threshold. Experiments are performed in a very large domain of concentration and molecular mass, up to 35% and 200 kDa respectively, previously unexplored. The variation of the dwell time as a function of molecular mass shows that the chains are extracted from the semi-dilute solution in contact with the pore by a reptation mechanism.
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Dates et versions

hal-02006520 , version 1 (22-03-2019)

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Abdel Ghani Oukhaled, Anne-Laure Biance, Juan Pelta, Loïc Auvray, Laurent Bacri. Transport of Long Neutral Polymers in the Semidilute Regime through a Protein Nanopore. Physical Review Letters, 2012, 108 (8), pp.088104. ⟨10.1103/PhysRevLett.108.088104⟩. ⟨hal-02006520⟩
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