Nowadays, the web 2.0 generation substitutes for the Young Generation and the digital native. Evolution of numeric technologies is a true revolution in health professions, particularly in oral health care. For years, video games have invaded our daily life. Besides, learning-play and role-play are recognized as an efficient teaching method. Now, Serious Game takes up an important place especially in the dental training and in the medical education. Serious Game allows to immerse e-learners in a 3D space and a 3D time to compare real clinical situations, and to be an actor of one’s training. The 3D virtual world has capacity to reproduce virtual reality as well as objects (3D imaging) and people (avatars). Furthermore, diagnosis and therapeutic choices are totally determined by the serious gamer. The e-learner evolves in the game step by step thanks to various questions to validate acquisition of scientific data and clinical knowledge. Development of Serious Games in oral medicine requires visualization effects, simulation context, and virtual reality thanks to design quality. Moreover, 3D simulators with feedback force’s arm is a very interesting perspective in terms of primary, graduate, postgraduate training and continuing education. In the near future, these new e-tools will emphasize dynamic and promising innovation of Learning Game, Awareness Game and Serious Games in Dentistry. The perspective of e-learning game is on the one hand to promulgate medical education based on simulation according to the ethical imperative, and on the other hand to have better dental surgeons giving better dental health care. References: •Chen-Yi Y., Yu-Sheng L., Chien-Tsai L. Developing an interactive dental casting educational game. Comput Sci Inform Technology 2010;437:40. •Konukseven EI., Onder ME., Mumcuoglu E., Kisnisci RS. Development of a visio-haptic integrated dental training simulation system. J Dent Educ 2010;74(8):880-91. •Lavergne-Boudier V., Dambach Y. Serious Game : révolution pédagogique. Editions Lavoisier 2010. •Means, B., Toyama, Y., Murphy, R., Bakia, M., & Jones, K. Evaluation of evidence-based practices in online learning: A meta-analysis and review of online learning studies. Report online 2009. http://www2.ed.gov/rschstat/eval/tech/evidence-based-practices/finalreport.pdf (Page consultée en ligne le 10/04/2012). •Welk A., Splieth Ch., Wierinck E., Gilpatrick RO., Meyer G. Computer-assisted learning and simulation systems in dentistry: a challenge to society. Int J Comput Dent 2006;9(3):253-6. •Welk A., Splieth Ch., Seyer D., Rosin M., Siemer M., Meyer G. German dental faculty attitudes towards computer-assisted simulation systems correlated with personal and professional profiles. Eur J Dent 2006;10(2):87-95. •Welk A., Maggio MP., Simon JF., Scarbecz M., Harrison JA., Wicks RA., Gilpatrick RO. Computer-assisted learning and simulation lab with 40 DentSim units. Int J Comput Dent 2008;11(1):17-40. •Ziv A., Wolpe PR., Small SD., Glick S. Simulation-based medical education: an ethical imperative. Acad Med. 2003;78(8):783–788.