Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers - Archive ouverte HAL Access content directly
Journal Articles Amino Acids Year : 2015

Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers

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Abstract

Racemic-protected α-ethynylphenylalanine was synthesized from dl-2-benzylserine using α-benzylserinal as key intermediate and was uccessfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism.
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hal-02002634 , version 1 (11-02-2019)

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Z Benfodda, David Bénimèlis, Marion Jean, Jean-Valère Naubron, Valerie Rolland, et al.. Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers. Amino Acids, 2015, 47 (5), pp.899-907. ⟨10.1007/s00726-015-1917-1⟩. ⟨hal-02002634⟩
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