Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers
Abstract
Racemic-protected α-ethynylphenylalanine was synthesized from dl-2-benzylserine using α-benzylserinal as key intermediate and was uccessfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism.
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