Temperature affects the biology of Schmidtea mediterranea - Archive ouverte HAL
Article Dans Une Revue Scientific Reports Année : 2018

Temperature affects the biology of Schmidtea mediterranea

Résumé

Studies of tissue regeneration and host-pathogen interactions using the model planarian Schmidtea mediterranea have been performed at an experimental temperature of 19 degrees C. S. mediterranea planarians exposed to 19 degrees C-32 degrees C were observed for survival, mobility, feeding and regeneration for three months and elimination of the Staphylococcus aureus pathogen over six days. S. mediterranea planarians died at 30 degrees C-32 degrees C after 18 days of observation but tolerated temperatures of 19 degrees C up to 28 degrees C with non-significant differences in mobility and feeding behavior. Genetic malleability tested by RNAi feeding was still efficient at 26 degrees C and 28 degrees C. Concerning the immune capacity of planarians, we reported an exacerbation of the immune response in worms infected by S. aureus at 26 degrees C and 28 degrees C. These observations suggest a temperature modulation of planarian stem cells and illustrate the importance of modulating experimental temperature when using planarians as model organisms to study regeneration and immune response.
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hal-02000573 , version 1 (28-09-2023)

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Nassim Hammoudi, Cedric Torre, Eric Ghigo, Michel Drancourt. Temperature affects the biology of Schmidtea mediterranea. Scientific Reports, 2018, 8, pp.14934. ⟨10.1038/s41598-018-33355-5⟩. ⟨hal-02000573⟩
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