<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01991824</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T06:34:36+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners</title>
            <author role="aut">
              <persName>
                <forename type="first">Liza</forename>
                <forename type="middle">L.</forename>
                <surname>Felicori</surname>
              </persName>
              <idno type="halauthorid">832390-0</idno>
              <affiliation ref="#struct-117573"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Katie</forename>
                <surname>Jameson</surname>
              </persName>
              <idno type="halauthorid">1506166-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Roblin</surname>
              </persName>
              <idno type="halauthorid">505397-0</idno>
              <affiliation ref="#struct-87540"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mark</forename>
                <forename type="middle">M.</forename>
                <surname>Fogg</surname>
              </persName>
              <idno type="halauthorid">832391-0</idno>
              <affiliation ref="#struct-255917"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Transito</forename>
                <surname>Garcia-Garcia</surname>
              </persName>
              <idno type="halauthorid">1506167-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Magali</forename>
                <surname>Ventroux</surname>
              </persName>
              <email type="md5">960cd0023a885057d0b1b628c2ea84e0</email>
              <email type="domain">inra.fr</email>
              <idno type="idhal" notation="string">magali-ventroux</idno>
              <idno type="idhal" notation="numeric">1319609</idno>
              <idno type="halauthorid" notation="string">937825-1319609</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5890-2929</idno>
              <affiliation ref="#struct-132919"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mickael V</forename>
                <surname>Cherrier</surname>
              </persName>
              <email type="md5">763330a424be72c3a2f4d28f26b670e0</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="string">cherriermv</idno>
              <idno type="idhal" notation="numeric">1397168</idno>
              <idno type="halauthorid" notation="string">919539-1397168</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0724-6663</idno>
              <idno type="IDREF">https://www.idref.fr/11055535X</idno>
              <idno type="ISNI">http://isni.org/isni/0000000140742947</idno>
              <idno type="VIAF">https://viaf.org/viaf/217324178</idno>
              <affiliation ref="#struct-576"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandre</forename>
                <surname>Bazin</surname>
              </persName>
              <idno type="idhal" notation="numeric">771117</idno>
              <idno type="halauthorid" notation="string">815065-771117</idno>
              <idno type="IDREF">https://www.idref.fr/190593954</idno>
              <affiliation ref="#struct-511411"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Noirot</surname>
              </persName>
              <email type="md5">547035d4ac0cc1fe296abf86501c8403</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">philippe-noirot3</idno>
              <idno type="idhal" notation="numeric">1145189</idno>
              <idno type="halauthorid" notation="string">345330-1145189</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3446-6987</idno>
              <affiliation ref="#struct-132919"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anthony</forename>
                <surname>Wilkinson</surname>
              </persName>
              <idno type="halauthorid">1506168-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Franck</forename>
                <surname>Molina</surname>
              </persName>
              <email type="md5">fe9d58cb527322ca01440d2ac8362810</email>
              <email type="domain">cpbs.univ-montp1.fr</email>
              <idno type="idhal" notation="numeric">757999</idno>
              <idno type="halauthorid" notation="string">206557-757999</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4181-0854</idno>
              <affiliation ref="#struct-117573"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Terradot</surname>
              </persName>
              <email type="md5">9dc2ad31bc80825debdcf9ef201c72c9</email>
              <email type="domain">ibcp.fr</email>
              <idno type="idhal" notation="string">terradot-laurent</idno>
              <idno type="idhal" notation="numeric">178188</idno>
              <idno type="halauthorid" notation="string">20448-178188</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4279-9167</idno>
              <idno type="IDREF">https://www.idref.fr/144304678</idno>
              <affiliation ref="#struct-227725"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Françoise</forename>
                <surname>Noirot-Gros</surname>
              </persName>
              <email type="md5">ed4ff983d1ddc886e94dcc035255b404</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">marie-francoise-noirot-gros</idno>
              <idno type="idhal" notation="numeric">748300</idno>
              <idno type="halauthorid" notation="string">33513-748300</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1661-3023</idno>
              <affiliation ref="#struct-132919"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Françoise</forename>
                <surname>Noirot</surname>
              </persName>
              <email type="md5">ed4ff983d1ddc886e94dcc035255b404</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">marie-francoise-noirot-gros</idno>
              <idno type="idhal" notation="numeric">748300</idno>
              <idno type="halauthorid" notation="string">1506169-748300</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1661-3023</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Frank</forename>
                <surname>Thomas</surname>
              </persName>
              <email type="md5">d93af13e6932f3e24cc9a230ad329114</email>
              <email type="domain">ibs.fr</email>
            </editor>
            <funder>European integrated project, BaSysBio ; Biotechnology and Biological Sciences Research Council, UK ; EU-Marie Curie Project AMBER FP7-People [317338] ; CIBLE program from the region Rhones-alpes; MICALIS INRA</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-05-27 04:29:05</date>
              <date type="whenModified">2026-04-30 03:14:57</date>
              <date type="whenReleased">2020-05-27 04:29:22</date>
              <date type="whenProduced">2016-01-08</date>
              <date type="whenEndEmbargoed">2020-05-27</date>
              <ref type="file" target="https://hal.univ-grenoble-alpes.fr/hal-01991824v1/document">
                <date notBefore="2020-05-27"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.univ-grenoble-alpes.fr/hal-01991824v1/file/2016_Felicori_Nucleic%20Acids%20Research_1.pdf" id="file-2629914-2458345">
                <date notBefore="2020-05-27"/>
              </ref>
              <ref type="externalLink" target="https://academic.oup.com/nar/article-pdf/44/1/449/18786601/gkv1318.pdf"/>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="139172">
                <persName>
                  <forename>Frank</forename>
                  <surname>Thomas</surname>
                </persName>
                <email type="md5">d93af13e6932f3e24cc9a230ad329114</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01991824</idno>
            <idno type="halUri">https://hal.univ-grenoble-alpes.fr/hal-01991824</idno>
            <idno type="halBibtex">felicori:hal-01991824</idno>
            <idno type="halRefHtml">&lt;i&gt;Nucleic Acids Research&lt;/i&gt;, 2016, 44 (1), pp.449-463. &lt;a target="_blank" href="https://dx.doi.org/10.1093/nar/gkv1318"&gt;&amp;#x27E8;10.1093/nar/gkv1318&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nucleic Acids Research, 2016, 44 (1), pp.449-463. &amp;#x27E8;10.1093/nar/gkv1318&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2629914-2458345"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="AGROPARISTECH">AgroParisTech</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="IBS" corresp="CEA">Institut de Biologie Structurale</idno>
            <idno type="stamp" n="IBS-MET" corresp="IBS">Groupe Métalloprotéines / Metalloproteins Group (IBS-METALLO)</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="AGROPARISTECH-SACLAY" corresp="UNIV-PARIS-SACLAY">AgroParisTech-Saclay</idno>
            <idno type="stamp" n="INRA-SACLAY" corresp="UNIV-PARIS-SACLAY">INRA-SACLAY</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UGA-COMUE">Université Grenoble Alpes [2016-2019]</idno>
            <idno type="stamp" n="GS-BIOSPHERA">Graduate School Biologie, Société, Ecologie &amp; Environnement, Ressources, Agriculture &amp; Alimentation</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="MICALIS">Micalis</idno>
            <idno type="stamp" n="B3D-MICALIS" corresp="MICALIS">Biofilms &amp; Spatially Organized Communities</idno>
            <idno type="stamp" n="MUSE-MICALIS" corresp="MICALIS">Mutagenesis in Single-Cells and Evolution</idno>
            <idno type="stamp" n="MMSB">Molecular Microbiology and Structural Biochemistry - UMR5086</idno>
            <idno type="stamp" n="APT_TEST">APT_TEST</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Liza</forename>
                    <forename type="middle">L.</forename>
                    <surname>Felicori</surname>
                  </persName>
                  <idno type="halauthorid">832390-0</idno>
                  <affiliation ref="#struct-117573"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Katie</forename>
                    <surname>Jameson</surname>
                  </persName>
                  <idno type="halauthorid">1506166-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Roblin</surname>
                  </persName>
                  <idno type="halauthorid">505397-0</idno>
                  <affiliation ref="#struct-87540"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mark</forename>
                    <forename type="middle">M.</forename>
                    <surname>Fogg</surname>
                  </persName>
                  <idno type="halauthorid">832391-0</idno>
                  <affiliation ref="#struct-255917"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Transito</forename>
                    <surname>Garcia-Garcia</surname>
                  </persName>
                  <idno type="halauthorid">1506167-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Magali</forename>
                    <surname>Ventroux</surname>
                  </persName>
                  <email type="md5">960cd0023a885057d0b1b628c2ea84e0</email>
                  <email type="domain">inra.fr</email>
                  <idno type="idhal" notation="string">magali-ventroux</idno>
                  <idno type="idhal" notation="numeric">1319609</idno>
                  <idno type="halauthorid" notation="string">937825-1319609</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5890-2929</idno>
                  <affiliation ref="#struct-132919"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mickael V</forename>
                    <surname>Cherrier</surname>
                  </persName>
                  <email type="md5">763330a424be72c3a2f4d28f26b670e0</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="string">cherriermv</idno>
                  <idno type="idhal" notation="numeric">1397168</idno>
                  <idno type="halauthorid" notation="string">919539-1397168</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0724-6663</idno>
                  <idno type="IDREF">https://www.idref.fr/11055535X</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000140742947</idno>
                  <idno type="VIAF">https://viaf.org/viaf/217324178</idno>
                  <affiliation ref="#struct-576"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandre</forename>
                    <surname>Bazin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">771117</idno>
                  <idno type="halauthorid" notation="string">815065-771117</idno>
                  <idno type="IDREF">https://www.idref.fr/190593954</idno>
                  <affiliation ref="#struct-511411"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Noirot</surname>
                  </persName>
                  <email type="md5">547035d4ac0cc1fe296abf86501c8403</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">philippe-noirot3</idno>
                  <idno type="idhal" notation="numeric">1145189</idno>
                  <idno type="halauthorid" notation="string">345330-1145189</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3446-6987</idno>
                  <affiliation ref="#struct-132919"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anthony</forename>
                    <surname>Wilkinson</surname>
                  </persName>
                  <idno type="halauthorid">1506168-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Franck</forename>
                    <surname>Molina</surname>
                  </persName>
                  <email type="md5">fe9d58cb527322ca01440d2ac8362810</email>
                  <email type="domain">cpbs.univ-montp1.fr</email>
                  <idno type="idhal" notation="numeric">757999</idno>
                  <idno type="halauthorid" notation="string">206557-757999</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4181-0854</idno>
                  <affiliation ref="#struct-117573"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Terradot</surname>
                  </persName>
                  <email type="md5">9dc2ad31bc80825debdcf9ef201c72c9</email>
                  <email type="domain">ibcp.fr</email>
                  <idno type="idhal" notation="string">terradot-laurent</idno>
                  <idno type="idhal" notation="numeric">178188</idno>
                  <idno type="halauthorid" notation="string">20448-178188</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4279-9167</idno>
                  <idno type="IDREF">https://www.idref.fr/144304678</idno>
                  <affiliation ref="#struct-227725"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Françoise</forename>
                    <surname>Noirot-Gros</surname>
                  </persName>
                  <email type="md5">ed4ff983d1ddc886e94dcc035255b404</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">marie-francoise-noirot-gros</idno>
                  <idno type="idhal" notation="numeric">748300</idno>
                  <idno type="halauthorid" notation="string">33513-748300</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1661-3023</idno>
                  <affiliation ref="#struct-132919"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Françoise</forename>
                    <surname>Noirot</surname>
                  </persName>
                  <email type="md5">ed4ff983d1ddc886e94dcc035255b404</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">marie-francoise-noirot-gros</idno>
                  <idno type="idhal" notation="numeric">748300</idno>
                  <idno type="halauthorid" notation="string">1506169-748300</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1661-3023</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">1850</idno>
                <idno type="issn">0305-1048</idno>
                <idno type="eissn">1362-4962</idno>
                <title level="j">Nucleic Acids Research</title>
                <imprint>
                  <publisher>Oxford University Press</publisher>
                  <biblScope unit="volume">44</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">449-463</biblScope>
                  <date type="datePub">2016-01-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/nar/gkv1318</idno>
              <idno type="prodinra">351843</idno>
              <idno type="pubmed">26615189</idno>
              <idno type="wos">000371264000045</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Amino Acid Motifs</classCode>
              <classCode scheme="mesh">Amino Acid Sequence</classCode>
              <classCode scheme="mesh">DNA-Binding Proteins</classCode>
              <classCode scheme="mesh">Intracellular Space</classCode>
              <classCode scheme="mesh">Multiprotein Complexes</classCode>
              <classCode scheme="mesh">Models, Molecular</classCode>
              <classCode scheme="mesh">Molecular Sequence Data</classCode>
              <classCode scheme="mesh">Mutation</classCode>
              <classCode scheme="mesh">Position-Specific Scoring Matrices</classCode>
              <classCode scheme="mesh">Protein Binding</classCode>
              <classCode scheme="mesh">Protein Conformation</classCode>
              <classCode scheme="mesh">Protein Interaction Domains and Motifs</classCode>
              <classCode scheme="mesh">Protein Transport</classCode>
              <classCode scheme="mesh">Protein Interaction Mapping</classCode>
              <classCode scheme="mesh">Protein Multimerization</classCode>
              <classCode scheme="mesh">Sequence Alignment</classCode>
              <classCode scheme="mesh">Bacillus subtilis</classCode>
              <classCode scheme="mesh">Structure-Activity Relationship</classCode>
              <classCode scheme="mesh">Zinc</classCode>
              <classCode scheme="mesh">Bacterial Proteins</classCode>
              <classCode scheme="mesh">Binding Sites</classCode>
              <classCode scheme="mesh">DNA Replication</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bs">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>YabA negatively regulates initiation of DNA replication in low-GC Gram-positive bacteria. The protein exerts its control through interactions with the initiator protein DnaA and the sliding clamp DnaN. Here, we combined X-ray crystallography, X-ray scattering (SAXS), modeling and biophysical approaches, with in vivo experimental data to gain insight into YabA function. The crystal structure of the N-terminal domain (NTD) of YabA solved at 2.7 Å resolution reveals an extended α-helix that contributes to an intermolecular four-helix bundle. Homology modeling and biochemical analysis indicates that the C-terminal domain (CTD) of YabA is a small Zn-binding domain. Multi-angle light scattering and SAXS demonstrate that YabA is a tetramer in which the CTDs are independent and connected to the N-terminal four-helix bundle via flexible linkers. While YabA can simultaneously interact with both DnaA and DnaN, we found that an isolated CTD can bind to either DnaA or DnaN, individually. Site-directed mutagenesis and yeast-two hybrid assays identified DnaA and DnaN binding sites on the YabA CTD that partially overlap and point to a mutually exclusive mode of interaction. Our study defines YabA as a novel structural hub and explains how the protein tetramer uses independent CTDs to bind multiple partners to orchestrate replication initiation in the bacterial cell.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-117573" status="OLD">
          <orgName>Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic</orgName>
          <orgName type="acronym">SysDiag</orgName>
          <date type="start">2009-01-01</date>
          <date type="end">2014-12-31</date>
          <desc>
            <address>
              <addrLine>CAP DELTA - 1682 RUE DE LA VALSIERE34184 MONTPELLIER CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.sys2diag.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300238" type="direct"/>
            <relation name="UMR3145" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-87540" status="OLD">
          <orgName>Département Caractérisation et Elaboration des Produits Issus de l'Agriculture</orgName>
          <orgName type="acronym">CEPIA</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Rue de la Géraudière B.P. 71627, 44316 Nantes Cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cepia.inra.fr</ref>
          </desc>
          <listRelation>
            <relation name="UAR1008" active="#struct-92114" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-255917" status="INCOMING">
          <orgName>York Structural Biology Laboratory, Department of Chemistry</orgName>
          <desc>
            <address>
              <addrLine>York</addrLine>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-124942" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-132919" status="OLD">
          <orgName>MICrobiologie de l'ALImentation au Service de la Santé</orgName>
          <orgName type="acronym">MICALIS</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>F-78350 JOUY-EN-JOSAS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.micalis.fr/micalis</ref>
          </desc>
          <listRelation>
            <relation name="UMR1319" active="#struct-92114" type="direct"/>
            <relation active="#struct-148117" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-576" status="OLD">
          <idno type="IdRef">06912633X</idno>
          <idno type="ISNI">0000 0004 0641 5776</idno>
          <idno type="RNSR">199911764W</idno>
          <idno type="ROR">https://ror.org/04szabx38</idno>
          <orgName>Institut de biologie structurale</orgName>
          <orgName type="acronym">IBS - UMR 5075</orgName>
          <date type="start">1992-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Institut de Biologie Structurale, 71 avenue des martyrs, CS 10090, 38044 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR5075 / UPR9015" active="#struct-441569" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
            <relation name="DRF/IRIG/DBSC" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-511411" status="VALID">
          <idno type="IdRef">226919544</idno>
          <idno type="RNSR">199411772B</idno>
          <idno type="ROR">00jv0wy06</idno>
          <orgName>Microbiologie moléculaire et biochimie structurale - Molecular Microbiology and Structural Biochemistry</orgName>
          <orgName type="acronym">MMSB</orgName>
          <date type="start">1999-01-01</date>
          <desc>
            <address>
              <addrLine>IBCP CNRS/Université de Lyon7 Passage du vercors69367 LYON Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://mmsb.cnrs.fr/en/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="UMR5086" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-227725" status="VALID">
          <idno type="RNSR">201622438Z</idno>
          <idno type="ROR">0019x5d05</idno>
          <orgName>Institut de biologie et chimie des protéines [Lyon]</orgName>
          <orgName type="acronym">IBCP</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>7 Passage du Vercors 69367 LYON CEDEX 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibcp.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="UAR3760 / UMR3760" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300238" status="VALID">
          <orgName>BIO-RAD</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-124942" status="VALID">
          <idno type="ROR">https://ror.org/04m01e293</idno>
          <orgName>University of York [York, UK]</orgName>
          <desc>
            <address>
              <addrLine>Heslington, York, YO10 5DD</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.york.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-148117" status="VALID">
          <idno type="IdRef">139408088</idno>
          <idno type="ROR">https://ror.org/02kbmgc12</idno>
          <orgName>AgroParisTech</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>22 place de l'Agronomie CS 20040 91123 Palaiseau cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.agroparistech.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>