Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecules Année : 2012

Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis

Nicolas Martin
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Soizic Prado
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Olivier Thomas
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Résumé

The first phytochemical inspection of the Marquesan endemic plant Rauvolfia nukuhivensis led to the isolation and structure characterization of two new indolo[2,3-a]quinolizinium derivatives named nukuhivensium and N₁₂-methyl-nukuhivensium. They feature an aromatic indolo[2,3-a]quinolizinium core, substituted at C-2 by a n-propyl group, which is unusual in this family of alkaloid derivatives. The structure elucidation was performed on the basis of NMR spectroscopy and especially by interpretation of 2D HMBC correlations. A biosynthetic pathway is proposed on the basis of known enzymatic transformations for this family of natural products. These compounds exhibited low antimicrobial activities.

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Dates et versions

hal-01991592 , version 1 (23-01-2019)

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  • HAL Id : hal-01991592 , version 1

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Nicolas Martin, Soizic Prado, Gaël Lecellier, Olivier Thomas, Phila Raharivelomanana. Nukuhivensiums, Indolo[2,3-a]quinoliziniums from the Marquesan Plant Rauvolfia nukuhivensis. Molecules, 2012, 17 (10), pp.12015-12022. ⟨hal-01991592⟩

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