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Article Dans Une Revue Current Opinion in Structural Biology Année : 2018

Lasers and ion mobility: new additions to the glycosaminoglycanomics toolkit

Résumé

Glycosaminoglycans are biopolymers present in mammalian cells or in the extracellular matrix. To address their structure, the nature of the hexuronic acids and the position of sulfate groups must be determined. Tandem mass spectrometry using collision induced dissociation or electron-based fragmentation techniques, is a well-established approach for the identification of glycans but suffers from the frequent lack of diagnostic fragments in the case of glycosaminoglycans. This review presents alternative fragmentation techniques, namely photofragmentation in the IR and the UV ranges. Alternative approaches based on the direct analysis of the molecular structure, including ion mobility spectrometry and ion spectroscopies are reviewed. The potential of future multidimensional workflows for glycosaminoglycanomics is discussed.
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Dates et versions

hal-01966719 , version 1 (29-12-2018)

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Isabelle Compagnon, Baptiste Schindler, Gina Renois-Predelus, Régis Daniel. Lasers and ion mobility: new additions to the glycosaminoglycanomics toolkit. Current Opinion in Structural Biology, 2018, 50, pp.171-180. ⟨10.1016/j.sbi.2018.06.006⟩. ⟨hal-01966719⟩
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