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Article Dans Une Revue Organic Letters Année : 2017

Pleiokomenines A and B: Dimeric Aspidofractinine Alkaloids Tethered with a Methylene Group

Résumé

Pleiokomenines A and B (1 and 2), first examples of dimeric aspidofractinine alkaloids linked by a methylene bridge, were isolated from the stem bark of Pleiocarpa mutica. Their structures were elucidated by a combination of spectroscopic analyses and semisynthetic derivatization of pleiocarpinine (3) and a formaldehyde equivalent mediated by scandium trifluoromethanesulfonate. Pleiokomenines A (1) and B (2) showed moderate antiplasmodial activities in the micromolar range against the FcB1 strain.
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hal-01966401 , version 1 (28-12-2018)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Elvis Otogo N’nang Obiang, Grégory Genta-Jouve, Jean-François Gallard, Brice Kumulungui, Elisabeth Mouray, et al.. Pleiokomenines A and B: Dimeric Aspidofractinine Alkaloids Tethered with a Methylene Group. Organic Letters, 2017, 19 (22), pp.6180-6183. ⟨10.1021/acs.orglett.7b03098⟩. ⟨hal-01966401⟩
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