The Multiple Layers of the Tumor Environment

The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.

Mots clés

immune system angiogenesis niche tumor organismal environment Tumor microenvironment

Domaines

Sciences du Vivant [q-bio] Cancer Biologie du développement Ecologie, Environnement Immunologie Sciences de l'Homme et Société Histoire, Philosophie et Sociologie des sciences

Fichier principal

Laplane-Duluc-Larmonier-Pradeu-Bikfalvi_The Multiple Layers of the Tumor Environment_Final draft.pdf (232.07 Ko)

Origine	Fichiers produits par l'(les) auteur(s)

Thomas Pradeu : Connectez-vous pour contacter le contributeur

https://hal.science/hal-01964545

Soumis le : samedi 22 décembre 2018-15:29:12

Dernière modification le : lundi 9 décembre 2024-15:36:03

Archivage à long terme le : samedi 23 mars 2019-12:27:23

Dates et versions

hal-01964545 , version 1 (22-12-2018)

Identifiants

HAL Id : hal-01964545 , version 1
DOI : 10.1016/j.trecan.2018.10.002

Citer

Lucie Laplane, Dorothee Duluc, Nicolas Larmonier, Thomas Pradeu, Andreas Bikfalvi. The Multiple Layers of the Tumor Environment. Trends in Cancer, 2018, 4 (12), pp.802-809. ⟨10.1016/j.trecan.2018.10.002⟩. ⟨hal-01964545⟩

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