Confinement-induced transition between wave-like collective cell migration modes: - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Physical Review Letters Année : 2019

Confinement-induced transition between wave-like collective cell migration modes:

Résumé

The structural and functional organization of biological tissues relies on the intricate interplay between chemical and mechanical signaling. Whereas the role of constant and transient mechanical perturbations is generally accepted, several studies recently highlighted the existence of longrange mechanical excitations (i.e., waves) at the supracellular level. Here, we confine epithelial cell mono-layers to quasi-one dimensional geometries, to force the establishment of tissue-level waves of well-defined wavelength and period. Numerical simulations based on a self-propelled Voronoi model reproduce the observed waves and exhibit a phase transition between a global and a multi-nodal wave, controlled by the confinement size. We con rm experimentally the existence of such a phase transition, and show that wavelength and period are independent of the confinement length. Together, these results demonstrate the intrinsic origin of tissue oscillations, which could provide cells with a mechanism to accurately measure distances at the supracellular level.
Fichier principal
Vignette du fichier
495747.full.pdf (3.75 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01958763 , version 1 (18-12-2018)

Identifiants

Citer

Vanni Petrolli, Magali Le Goff, Monika Tadrous, Kirsten Martens, Cédric Allier, et al.. Confinement-induced transition between wave-like collective cell migration modes:. Physical Review Letters, 2019, 122 (16), pp.168101. ⟨10.1103/PhysRevLett.122.168101⟩. ⟨hal-01958763⟩

Relations

220 Consultations
149 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More