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Article Dans Une Revue Molecules Année : 2018

Anticancer and anti-inflammatory activities of some new pyrazolo[3,4-b]pyrazines

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New derivatives of pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized using 5-amino-3-methyl-4-nitroso-1-phenyl-pyrazole (1) as a starting material. The 5-acetyl derivative 15 was shown to be a useful key intermediate for the synthesis of several derivatives of pyrazolopyrazines. Some of the prepared compounds were evaluated for their anti-inflammatory and anti-breast cancer MCF-7 cell line activities. SAR study showed that compounds 15 and 29 exhibited remarkable anti-inflammatory activity, where 15 showed the same activity as that of the reference drug indomethacin. On the other hand, compounds 25i, 25j showed very significant inhibitory activity (p < 0.001) against MCF-7 breast cancer cell line.
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hal-01954194 , version 1 (25-10-2019)

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Hussein El-Kashef, Talaat El-Emary, Pierre Verhaeghe, P. Vanelle, Maha Samy. Anticancer and anti-inflammatory activities of some new pyrazolo[3,4-b]pyrazines. Molecules, 2018, 23 (10), pp.2657. ⟨10.3390/molecules23102657⟩. ⟨hal-01954194⟩
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