<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01945151</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T02:18:35+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population</title>
            <author role="aut">
              <persName>
                <forename type="first">Matthieu</forename>
                <surname>Wargny</surname>
              </persName>
              <email type="md5">7a113fd445d747e19d302aeae0e18338</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">1092281</idno>
              <idno type="halauthorid" notation="string">1167062-1092281</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6027-9486</idno>
              <idno type="IDREF">https://www.idref.fr/199131872</idno>
              <affiliation ref="#struct-182196"/>
              <affiliation ref="#struct-417880"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Henri</forename>
                <surname>Ducluzeau</surname>
              </persName>
              <email type="md5">8569cf810e5bc4b94dca90352be86ce3</email>
              <email type="domain">chu-tours.fr</email>
              <idno type="idhal" notation="string">pierre-henri-ducluzeau</idno>
              <idno type="idhal" notation="numeric">744425</idno>
              <idno type="halauthorid" notation="string">3859-744425</idno>
              <idno type="IDREF">https://www.idref.fr/074522043</idno>
              <affiliation ref="#struct-179009"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Michel</forename>
                <surname>Petit</surname>
              </persName>
              <idno type="halauthorid">357708-0</idno>
              <affiliation ref="#struct-426438"/>
              <affiliation ref="#struct-489317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cedric</forename>
                <surname>Le May</surname>
              </persName>
              <idno type="halauthorid">51853-0</idno>
              <affiliation ref="#struct-182196"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sarra</forename>
                <surname>Smati</surname>
              </persName>
              <email type="md5">8d360403f044cac29d7d16cb6b993e47</email>
              <email type="domain">hotmail.com</email>
              <idno type="idhal" notation="numeric">1040023</idno>
              <idno type="halauthorid" notation="string">1239481-1040023</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5749-983X</idno>
              <idno type="IDREF">https://www.idref.fr/195233158</idno>
              <affiliation ref="#struct-182196"/>
              <affiliation ref="#struct-417880"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lucie</forename>
                <surname>Arnaud</surname>
              </persName>
              <idno type="halauthorid">968506-0</idno>
              <affiliation ref="#struct-182196"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Matthieu</forename>
                <surname>Pichelin</surname>
              </persName>
              <idno type="halauthorid">968505-0</idno>
              <affiliation ref="#struct-182196"/>
              <affiliation ref="#struct-417880"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <forename type="middle">Bouillet</forename>
                <surname>Bouillet</surname>
              </persName>
              <idno type="halauthorid">903150-0</idno>
              <affiliation ref="#struct-426438"/>
              <affiliation ref="#struct-489317"/>
              <affiliation ref="#struct-115314"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adrien</forename>
                <surname>Lannes</surname>
              </persName>
              <idno type="halauthorid">1473217-0</idno>
              <affiliation ref="#struct-151939"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Odile</forename>
                <surname>Blanchet</surname>
              </persName>
              <email type="md5">3556f1244b7a15a3f65760d9a35bf7fd</email>
              <email type="domain">chu-angers.fr</email>
              <idno type="idhal" notation="string">odile-blanchet</idno>
              <idno type="idhal" notation="numeric">749083</idno>
              <idno type="halauthorid" notation="string">18724-749083</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8275-8741</idno>
              <idno type="IDREF">https://www.idref.fr/117357383</idno>
              <affiliation ref="#struct-151939"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Lefebvre</surname>
              </persName>
              <email type="md5">f108c5f7867b57929aa5a3ff59beae68</email>
              <email type="domain">lille.inserm.fr</email>
              <idno type="idhal" notation="numeric">833880</idno>
              <idno type="halauthorid" notation="string">34193-833880</idno>
              <affiliation ref="#struct-106182"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sven</forename>
                <surname>Francque</surname>
              </persName>
              <idno type="halauthorid">1473218-0</idno>
              <affiliation ref="#struct-548605"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luc</forename>
                <surname>van Gaal</surname>
              </persName>
              <idno type="halauthorid">240146-0</idno>
              <affiliation ref="#struct-548606"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bart</forename>
                <surname>Staels</surname>
              </persName>
              <email type="md5">39d3eefb735a605ee2b675c53314ca12</email>
              <email type="domain">pasteur-lille.fr</email>
              <idno type="idhal" notation="string">bart-staels</idno>
              <idno type="idhal" notation="numeric">735802</idno>
              <idno type="halauthorid" notation="string">4916-735802</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/N-9497-2016</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3784-1503</idno>
              <idno type="IDREF">https://www.idref.fr/075009838</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/N-9497-2016</idno>
              <affiliation ref="#struct-106182"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Vergès</surname>
              </persName>
              <idno type="halauthorid">653140-0</idno>
              <affiliation ref="#struct-426438"/>
              <affiliation ref="#struct-489317"/>
              <affiliation ref="#struct-115314"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jérôme</forename>
                <surname>Boursier</surname>
              </persName>
              <email type="md5">60d62123e21b758787413ba006880b52</email>
              <email type="domain">chu-angers.fr</email>
              <idno type="idhal" notation="numeric">916784</idno>
              <idno type="halauthorid" notation="string">355165-916784</idno>
              <affiliation ref="#struct-151939"/>
              <affiliation ref="#struct-245050"/>
              <affiliation ref="#struct-504917"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Bertrand</forename>
                <surname>Cariou</surname>
              </persName>
              <email type="md5">1eed1f2b671cbc31cf91c6a2af157d87</email>
              <email type="domain">univ-nantes.fr</email>
              <idno type="idhal" notation="numeric">761594</idno>
              <idno type="halauthorid" notation="string">410249-761594</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1580-8040</idno>
              <idno type="IDREF">https://www.idref.fr/075934981</idno>
              <affiliation ref="#struct-182196"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>LNC -</forename>
                <surname>université de Bourgogne</surname>
              </persName>
              <email type="md5">2aa4993dcc040fcc29a08210ceac43ad</email>
              <email type="domain">u-bourgogne.fr</email>
            </editor>
            <funder ref="#projanr-49203"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-12-05 10:49:22</date>
              <date type="whenModified">2026-04-14 17:06:46</date>
              <date type="whenReleased">2018-12-05 10:49:22</date>
              <date type="whenProduced">2018-11</date>
              <ref type="externalLink" target="https://repository.uantwerpen.be/docman/irua/b5bff0/156326_2019_05_01.pdf"/>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="456690">
                <persName>
                  <forename>LNC -</forename>
                  <surname>université de Bourgogne</surname>
                </persName>
                <email type="md5">2aa4993dcc040fcc29a08210ceac43ad</email>
                <email type="domain">u-bourgogne.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01945151</idno>
            <idno type="halUri">https://hal.science/hal-01945151</idno>
            <idno type="halBibtex">wargny:hal-01945151</idno>
            <idno type="halRefHtml">&lt;i&gt;Atherosclerosis&lt;/i&gt;, 2018, 278, pp.82-90. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.atherosclerosis.2018.09.008"&gt;&amp;#x27E8;10.1016/j.atherosclerosis.2018.09.008&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Atherosclerosis, 2018, 278, pp.82-90. &amp;#x27E8;10.1016/j.atherosclerosis.2018.09.008&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="UNIV-BOURGOGNE">Université Bourgogne Europe</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="RIIP_LILLE" corresp="RIIP">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="LNC-UMR866" corresp="UNIV-BOURGOGNE">Lipides Nutrition Cancer - UMR866</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="LNC-PADYS" corresp="UNIV-BOURGOGNE">Lipides Nutrition Cancer - Equipe PADYS</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="THORAX-UMR">L'unité de recherche de l'institut du thorax (INSERM UMR1087, CNRS UMR6291)</idno>
            <idno type="stamp" n="HIFIH" corresp="UNIV-ANGERS">Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques</idno>
            <idno type="stamp" n="RNMCD">Récepteurs nucléaires, maladies cardiovasculaires et diabète</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
            <idno type="stamp" n="INSTITUT-AGRO">Institut Agro</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
            <idno type="stamp" n="CTM_UMR1231" corresp="UNIV-BOURGOGNE">CTM</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">IF 4.467 (2017)</note>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Matthieu</forename>
                    <surname>Wargny</surname>
                  </persName>
                  <email type="md5">7a113fd445d747e19d302aeae0e18338</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">1092281</idno>
                  <idno type="halauthorid" notation="string">1167062-1092281</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6027-9486</idno>
                  <idno type="IDREF">https://www.idref.fr/199131872</idno>
                  <affiliation ref="#struct-182196"/>
                  <affiliation ref="#struct-417880"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Henri</forename>
                    <surname>Ducluzeau</surname>
                  </persName>
                  <email type="md5">8569cf810e5bc4b94dca90352be86ce3</email>
                  <email type="domain">chu-tours.fr</email>
                  <idno type="idhal" notation="string">pierre-henri-ducluzeau</idno>
                  <idno type="idhal" notation="numeric">744425</idno>
                  <idno type="halauthorid" notation="string">3859-744425</idno>
                  <idno type="IDREF">https://www.idref.fr/074522043</idno>
                  <affiliation ref="#struct-179009"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Michel</forename>
                    <surname>Petit</surname>
                  </persName>
                  <idno type="halauthorid">357708-0</idno>
                  <affiliation ref="#struct-426438"/>
                  <affiliation ref="#struct-489317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cedric</forename>
                    <surname>Le May</surname>
                  </persName>
                  <idno type="halauthorid">51853-0</idno>
                  <affiliation ref="#struct-182196"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sarra</forename>
                    <surname>Smati</surname>
                  </persName>
                  <email type="md5">8d360403f044cac29d7d16cb6b993e47</email>
                  <email type="domain">hotmail.com</email>
                  <idno type="idhal" notation="numeric">1040023</idno>
                  <idno type="halauthorid" notation="string">1239481-1040023</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5749-983X</idno>
                  <idno type="IDREF">https://www.idref.fr/195233158</idno>
                  <affiliation ref="#struct-182196"/>
                  <affiliation ref="#struct-417880"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lucie</forename>
                    <surname>Arnaud</surname>
                  </persName>
                  <idno type="halauthorid">968506-0</idno>
                  <affiliation ref="#struct-182196"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Matthieu</forename>
                    <surname>Pichelin</surname>
                  </persName>
                  <idno type="halauthorid">968505-0</idno>
                  <affiliation ref="#struct-182196"/>
                  <affiliation ref="#struct-417880"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <forename type="middle">Bouillet</forename>
                    <surname>Bouillet</surname>
                  </persName>
                  <idno type="halauthorid">903150-0</idno>
                  <affiliation ref="#struct-426438"/>
                  <affiliation ref="#struct-489317"/>
                  <affiliation ref="#struct-115314"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adrien</forename>
                    <surname>Lannes</surname>
                  </persName>
                  <idno type="halauthorid">1473217-0</idno>
                  <affiliation ref="#struct-151939"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Odile</forename>
                    <surname>Blanchet</surname>
                  </persName>
                  <email type="md5">3556f1244b7a15a3f65760d9a35bf7fd</email>
                  <email type="domain">chu-angers.fr</email>
                  <idno type="idhal" notation="string">odile-blanchet</idno>
                  <idno type="idhal" notation="numeric">749083</idno>
                  <idno type="halauthorid" notation="string">18724-749083</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8275-8741</idno>
                  <idno type="IDREF">https://www.idref.fr/117357383</idno>
                  <affiliation ref="#struct-151939"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Lefebvre</surname>
                  </persName>
                  <email type="md5">f108c5f7867b57929aa5a3ff59beae68</email>
                  <email type="domain">lille.inserm.fr</email>
                  <idno type="idhal" notation="numeric">833880</idno>
                  <idno type="halauthorid" notation="string">34193-833880</idno>
                  <affiliation ref="#struct-106182"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sven</forename>
                    <surname>Francque</surname>
                  </persName>
                  <idno type="halauthorid">1473218-0</idno>
                  <affiliation ref="#struct-548605"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luc</forename>
                    <surname>van Gaal</surname>
                  </persName>
                  <idno type="halauthorid">240146-0</idno>
                  <affiliation ref="#struct-548606"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bart</forename>
                    <surname>Staels</surname>
                  </persName>
                  <email type="md5">39d3eefb735a605ee2b675c53314ca12</email>
                  <email type="domain">pasteur-lille.fr</email>
                  <idno type="idhal" notation="string">bart-staels</idno>
                  <idno type="idhal" notation="numeric">735802</idno>
                  <idno type="halauthorid" notation="string">4916-735802</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/N-9497-2016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3784-1503</idno>
                  <idno type="IDREF">https://www.idref.fr/075009838</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/N-9497-2016</idno>
                  <affiliation ref="#struct-106182"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Vergès</surname>
                  </persName>
                  <idno type="halauthorid">653140-0</idno>
                  <affiliation ref="#struct-426438"/>
                  <affiliation ref="#struct-489317"/>
                  <affiliation ref="#struct-115314"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jérôme</forename>
                    <surname>Boursier</surname>
                  </persName>
                  <email type="md5">60d62123e21b758787413ba006880b52</email>
                  <email type="domain">chu-angers.fr</email>
                  <idno type="idhal" notation="numeric">916784</idno>
                  <idno type="halauthorid" notation="string">355165-916784</idno>
                  <affiliation ref="#struct-151939"/>
                  <affiliation ref="#struct-245050"/>
                  <affiliation ref="#struct-504917"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Bertrand</forename>
                    <surname>Cariou</surname>
                  </persName>
                  <email type="md5">1eed1f2b671cbc31cf91c6a2af157d87</email>
                  <email type="domain">univ-nantes.fr</email>
                  <idno type="idhal" notation="numeric">761594</idno>
                  <idno type="halauthorid" notation="string">410249-761594</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1580-8040</idno>
                  <idno type="IDREF">https://www.idref.fr/075934981</idno>
                  <affiliation ref="#struct-182196"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">10870</idno>
                <idno type="issn">0021-9150</idno>
                <idno type="eissn">1879-1484</idno>
                <title level="j">Atherosclerosis</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">278</biblScope>
                  <biblScope unit="pp">82-90</biblScope>
                  <date type="datePub">2018-11</date>
                  <date type="dateEpub">2018-09-13</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.atherosclerosis.2018.09.008</idno>
              <idno type="prodinra">455830</idno>
              <idno type="pubmed">30261472</idno>
              <idno type="wos">000451056500011</idno>
              <ref type="publisher">https://www.sciencedirect.com/science/article/pii/S0021915018313704?via%3Dihub</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Liver steatosis</term>
                <term xml:lang="en">Liver fibrosis</term>
                <term xml:lang="en">Liver biopsy</term>
                <term xml:lang="en">LDL-cholesterol</term>
                <term xml:lang="en">MRI</term>
                <term xml:lang="en">PCSK9</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.mhep.em">Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism</classCode>
              <classCode scheme="vocinrae-old" n="pro protéine convertase">pro protéine convertase</classCode>
              <classCode scheme="vocinrae-old" n="activité hépatique">activité hépatique</classCode>
              <classCode scheme="vocinrae-old" n="cholestérol">cholestérol</classCode>
              <classCode scheme="vocinrae-old" n="fibrose">fibrose</classCode>
              <classCode scheme="vocinrae-old" n="stéatose hépatique">stéatose hépatique</classCode>
              <classCode scheme="vocinrae-old" n="foie">foie</classCode>
              <classCode scheme="vocinrae-old" n="imagerie par résonance magnétique">imagerie par résonance magnétique</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background and aimsSome studies suggested that proprotein convertase subtilisin kexin type 9 (PCSK9) is linked to liver steatosis severity and non-alcoholic steatohepatitis (NASH). We aimed to assess whether circulating PCSK9 levels are associated with either liver fat content (LFC) or histological markers of NASH in high-risk patients.MethodsWe present results from three cross-sectional studies from two French Hospitals: Dijon and Numevox (departments of Endocrinology) and Angers (department of Hepatology). Only patients without lipid-lowering therapy were included. All 132 patients had type 2 diabetes in Dijon, compared to 55/224 in Numevox (25%) and 39/122 in Angers (32%). LFC was assessed on MRI (Dijon and Numevox), and NASH lesion on liver biopsy (Angers). Additionally, we included mRNA results from 138 overweight patients of a Belgian Hospital (Antwerp).ResultsWhile circulating levels of PCSK9 were positively correlated with total cholesterol, LDL-C, triglycerides and non-HDL-C in all 3 cohorts, no significant association was found between PCSK9 and transaminases. Furthermore, no association was found between plasma PCSK9 levels and LFC in both Numevox (βadjusted = 0.71 ± 1.33, p = 0.60) and Dijon (βadjusted = −1.03 ± 0.90, p = 0.25). There was no correlation between circulating PCSK9 and histological liver lesions: steatosis severity (βadjusted = −3.95 ± 2.75, p = 0.15), NASH activity score (βadjusted = −0.31 ± 0.17, p = 0.082), lobular (β = −0.067 ± 0.055, p = 0.22) or portal inflammation (β = −0.088 ± 0.079, p = 0.27), ballooning (β = −0.025 ± 0.065, p = 0.70) and fibrosis (β = −0.17 ± 0.11, p = 0.12). Finally, hepatic PCSK9 mRNA levels were not correlated with NASH histological severity.ConclusionsCirculating PCSK9 concentrations are not associated with the severity of liver steatosis or histological markers of NASH. These data are reassuring regarding the clinical use of PCSK9 inhibitors in cardiovascular diseases.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-182196" status="OLD">
          <idno type="IdRef">190708026</idno>
          <idno type="RNSR">201220396X</idno>
          <orgName>ITX - unité de recherche de l'institut du thorax</orgName>
          <orgName type="acronym">ITX</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umr1087.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1087" active="#struct-303623" type="direct"/>
            <relation name="UMR6291" active="#struct-441569" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-417880" status="OLD">
          <orgName>Centre d’Investigation Clinique de Nantes</orgName>
          <orgName type="acronym">CIC Nantes</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Maison de la Recherche en Santé - 63 quai Magellan - 2éme étage Hall B - 44021 Nantes Cedex 1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
            <relation name="CIC 1413" active="#struct-303623" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-179009" status="VALID">
          <idno type="ROR">https://ror.org/00jpq0w62</idno>
          <orgName>Centre Hospitalier Régional Universitaire de Tours</orgName>
          <orgName type="acronym">CHRU Tours</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Régional Universitaire de Tours2 Boulevard Tonnellé 37044 Tours cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-tours.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-426438" status="VALID">
          <idno type="IdRef">200716271</idno>
          <idno type="ISNI">0000 0004 4910 6615</idno>
          <idno type="ROR">https://ror.org/02dn7x778</idno>
          <orgName>Université Bourgogne Franche-Comté [COMUE]</orgName>
          <orgName type="acronym">UBFC</orgName>
          <date type="start">2015-04-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>32, avenue de l’observatoire25000 BESANCON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-489317" status="OLD">
          <idno type="IdRef">15975979X</idno>
          <idno type="RNSR">200716508T</idno>
          <idno type="ROR">https://ror.org/04d70nb60</idno>
          <orgName>Lipides - Nutrition - Cancer [Dijon - U1231]</orgName>
          <orgName type="acronym">LNC</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Bourgogne - Faculte de medecine - 7, boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://inserm-u866.u-bourgogne.fr/index.php</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300270" type="direct"/>
            <relation name="U1231" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 866" active="#struct-415469" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-115314" status="VALID">
          <orgName>Service d'Endocrinologie, Diabétologie et Maladies Métaboliques (CHU de Dijon)</orgName>
          <desc>
            <address>
              <addrLine>CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-dijon.fr/fr/service/endocrinologie-diabetologie-maladies-metaboliques</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300924" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-106182" status="OLD">
          <idno type="IdRef">18838944X</idno>
          <idno type="RNSR">201019064H</idno>
          <orgName>Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011</orgName>
          <orgName type="acronym">RNMCD</orgName>
          <date type="start">2010-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue du Prof Calmette - 59019 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u1011.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1011" active="#struct-303623" type="direct"/>
            <relation name="U1011" active="#struct-374570" type="direct"/>
            <relation active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-548605" status="INCOMING">
          <orgName>Department of Gastroenterology and Hepatology (Antwerp University Hospital)</orgName>
          <desc>
            <address>
              <addrLine>Antwerp University Hospital –   Gastroenterology and HepatologyWilrijkstraat 10, 2650 Edegem, B</addrLine>
              <country key="BE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-309753" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-548606" status="INCOMING">
          <orgName>Department of Endocrinology, Diabetology and Metabolism (Antwerp University Hospital)</orgName>
          <desc>
            <address>
              <country key="BE"/>
            </address>
            <ref type="url">https://www.uantwerpen.be/en/research-groups/lemp/research-topics/endocrinology--diabetology/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-309753" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-245050" status="VALID">
          <idno type="RNSR">200415119W</idno>
          <orgName>Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques</orgName>
          <orgName type="acronym">HIFIH</orgName>
          <date type="start">2004-01-01</date>
          <desc>
            <address>
              <addrLine>Institut de Biologie en Santé, Iris 4 Rue Larrey, CHU, 49933 Angers</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-angers.fr/fr/recherche/la-recherche-a-l-ua/nos-structures-de-recherche/sante/hifih.html#!</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-504917" status="VALID">
          <orgName>Plateforme d'Analyse Cellulaire et Moléculaire [SFR ICAT - UA]</orgName>
          <orgName type="acronym">PACEM</orgName>
          <desc>
            <address>
              <addrLine>PACeM02 44 68 85 75Bâtiment IBS-IRIS (2ème étage)CHU Angers4, rue Larrey49933 Angers Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://sfricat.univ-angers.fr/fr/plateformes/pacem-analyse-cellulaire-et-moleculaire.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-549938" type="direct"/>
            <relation name="SFR 4208" active="#struct-74911" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300270" status="OLD">
          <idno type="IdRef">02819005X</idno>
          <idno type="ISNI">0000000122989313</idno>
          <idno type="ROR">https://ror.org/03k1bsr36</idno>
          <orgName>Université de Bourgogne</orgName>
          <orgName type="acronym">UB</orgName>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bourgogne.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-415469" status="OLD">
          <idno type="IdRef">13996634X</idno>
          <idno type="ROR">https://ror.org/03zek0r74</idno>
          <orgName>AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement</orgName>
          <date type="start">2009-03-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.agrosupdijon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300924" status="VALID">
          <idno type="ROR">https://ror.org/0377z4z10</idno>
          <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName>
          <orgName type="acronym">CHU Dijon</orgName>
          <desc>
            <address>
              <addrLine>14 rue Paul Gaffarel - 21079 Dijon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-dijon.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300166" status="VALID">
          <idno type="ROR">https://ror.org/05k9skc85</idno>
          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>
            <address>
              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-309753" status="VALID">
          <orgName>Antwerp University Hospital [Edegem]</orgName>
          <orgName type="acronym">UZA</orgName>
          <desc>
            <address>
              <addrLine>Hôpital universitaire d’AnversWilrijkstraat 102650 Edegem</addrLine>
              <country key="BE"/>
            </address>
            <ref type="url">https://www.uza.be/english</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-549938" status="VALID">
          <idno type="RNSR">200419826M</idno>
          <orgName>SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques</orgName>
          <orgName type="acronym">ICAT</orgName>
          <date type="start">2004-01-01</date>
          <desc>
            <address>
              <addrLine>SFR 4208, Bâtiment PBH-IRIS, 4 Rue Larrey, CHU Angers, 49933 ANGERS Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.icat4208.univ-angers.fr/</ref>
          </desc>
          <listRelation>
            <relation name="SFR 4208" active="#struct-74911" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-49203" status="VALID">
          <idno type="anr">ANR-16-RHUS-0007</idno>
          <orgName>CHOPIN</orgName>
          <desc>CHOPIN</desc>
          <date type="start">2016</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>