RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2
Mots clés
Humans
Male
Animals
Mice
Inbred C57BL
Disease Models
Animal
Ataxia
HEK293 Cells
Cerebellum
Transgenic
Membrane Potentials/drug effects/genetics
Mouse
Acetazolamide
Ataxia/*etiology/genetics/pathology/physiopathology
Calcium Channels
N-Type/genetics/*metabolism
Cerebellum/metabolism/*pathology
Green Fluorescent Proteins/genetics/metabolism
Movement/physiology
Nystagmus
Pathologic/*etiology/genetics/pathology/physiopathology
P/Q-type calcium channel
Postural Balance/genetics
Purkinje Cells/*metabolism
Purkinje neuron
RNA interference
RNA Interference/*physiology
RNA
Small Interfering/genetics/*physiology
Transduction
Genetic