<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01938164</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-12T22:44:14+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations</title>
            <author role="aut">
              <persName>
                <forename type="first">Haoues</forename>
                <surname>Alout</surname>
              </persName>
              <email type="md5">92013fe69a447e792946ec49354a807d</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">haoues-alout</idno>
              <idno type="idhal" notation="numeric">736940</idno>
              <idno type="halauthorid" notation="string">48193-736940</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7917-2697</idno>
              <idno type="IDREF">https://www.idref.fr/133842266</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/N-9556-2016</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=syZMq-AAAAAJ</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/N-9556-2016</idno>
              <affiliation ref="#struct-29770"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierrick</forename>
                <surname>Labbe</surname>
              </persName>
              <email type="md5">3530bfe141b696e34dc9b1e4f17c8f38</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">pierrick-labbe</idno>
              <idno type="idhal" notation="numeric">170293</idno>
              <idno type="halauthorid" notation="string">1326369-170293</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0806-1919</idno>
              <idno type="IDREF">https://www.idref.fr/073980854</idno>
              <affiliation ref="#struct-29770"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Berthomieu</surname>
              </persName>
              <email type="md5">d2a4339959e86058def8ddee2c2b6d39</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="numeric">1313920</idno>
              <idno type="halauthorid" notation="string">238805-1313920</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0931-667X</idno>
              <affiliation ref="#struct-29770"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicole</forename>
                <surname>Pasteur</surname>
              </persName>
              <email type="md5">0c6ab7c476565360b8b68423c9692d2b</email>
              <email type="domain">univ-montp2.fr</email>
              <idno type="idhal" notation="numeric">845614</idno>
              <idno type="halauthorid" notation="string">239882-845614</idno>
              <affiliation ref="#struct-29770"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mylène</forename>
                <surname>Weill</surname>
              </persName>
              <email type="md5">07f59d77423d823531befeb42fcd6be2</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">mylene-weill</idno>
              <idno type="idhal" notation="numeric">170754</idno>
              <idno type="halauthorid" notation="string">5489-170754</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4043-1601</idno>
              <idno type="IDREF">https://www.idref.fr/101516495</idno>
              <affiliation ref="#struct-29770"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pierrick</forename>
                <surname>Labbé</surname>
              </persName>
              <email type="md5">3530bfe141b696e34dc9b1e4f17c8f38</email>
              <email type="domain">umontpellier.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-12-06 11:38:58</date>
              <date type="whenModified">2026-05-12 16:50:01</date>
              <date type="whenReleased">2018-12-06 11:38:58</date>
              <date type="whenProduced">2009-12</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/6H6-6C06KLB0-N/fulltext.pdf?sid=hal"/>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="675072">
                <persName>
                  <forename>Pierrick</forename>
                  <surname>Labbé</surname>
                </persName>
                <email type="md5">3530bfe141b696e34dc9b1e4f17c8f38</email>
                <email type="domain">umontpellier.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01938164</idno>
            <idno type="halUri">https://hal.science/hal-01938164</idno>
            <idno type="halBibtex">alout:hal-01938164</idno>
            <idno type="halRefHtml">&lt;i&gt;Insect Biochemistry and Molecular Biology&lt;/i&gt;, 2009, 39 (12), pp.884 - 891. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ibmb.2009.10.005"&gt;&amp;#x27E8;10.1016/j.ibmb.2009.10.005&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Insect Biochemistry and Molecular Biology, 2009, 39 (12), pp.884 - 891. &amp;#x27E8;10.1016/j.ibmb.2009.10.005&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CIRAD">CIRAD - Centre de coopération internationale en recherche agronomique pour le développement</idno>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="ISEM" corresp="UNIV-MONTPELLIER">Institut des Sciences de l'Evolution</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="AGROPOLIS">Agropolis</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="B3ESTE">Biologie, Ecologie, Evolution, Environnement, Sciences de la Terre et de l'Eau</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Haoues</forename>
                    <surname>Alout</surname>
                  </persName>
                  <email type="md5">92013fe69a447e792946ec49354a807d</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">haoues-alout</idno>
                  <idno type="idhal" notation="numeric">736940</idno>
                  <idno type="halauthorid" notation="string">48193-736940</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7917-2697</idno>
                  <idno type="IDREF">https://www.idref.fr/133842266</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/N-9556-2016</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=syZMq-AAAAAJ</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/N-9556-2016</idno>
                  <affiliation ref="#struct-29770"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierrick</forename>
                    <surname>Labbe</surname>
                  </persName>
                  <email type="md5">3530bfe141b696e34dc9b1e4f17c8f38</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">pierrick-labbe</idno>
                  <idno type="idhal" notation="numeric">170293</idno>
                  <idno type="halauthorid" notation="string">1326369-170293</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0806-1919</idno>
                  <idno type="IDREF">https://www.idref.fr/073980854</idno>
                  <affiliation ref="#struct-29770"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Berthomieu</surname>
                  </persName>
                  <email type="md5">d2a4339959e86058def8ddee2c2b6d39</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="numeric">1313920</idno>
                  <idno type="halauthorid" notation="string">238805-1313920</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0931-667X</idno>
                  <affiliation ref="#struct-29770"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicole</forename>
                    <surname>Pasteur</surname>
                  </persName>
                  <email type="md5">0c6ab7c476565360b8b68423c9692d2b</email>
                  <email type="domain">univ-montp2.fr</email>
                  <idno type="idhal" notation="numeric">845614</idno>
                  <idno type="halauthorid" notation="string">239882-845614</idno>
                  <affiliation ref="#struct-29770"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mylène</forename>
                    <surname>Weill</surname>
                  </persName>
                  <email type="md5">07f59d77423d823531befeb42fcd6be2</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">mylene-weill</idno>
                  <idno type="idhal" notation="numeric">170754</idno>
                  <idno type="halauthorid" notation="string">5489-170754</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4043-1601</idno>
                  <idno type="IDREF">https://www.idref.fr/101516495</idno>
                  <affiliation ref="#struct-29770"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">14224</idno>
                <idno type="issn">0965-1748</idno>
                <title level="j">Insect Biochemistry and Molecular Biology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">39</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">884 - 891</biblScope>
                  <date type="datePub">2009-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ibmb.2009.10.005</idno>
              <idno type="prodinra">452659</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.bid.evo">Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]</classCode>
              <classCode scheme="halDomain" n="sdv.gen.gpo">Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]</classCode>
              <classCode scheme="halDomain" n="sdv.ee.eco">Life Sciences [q-bio]/Ecology, environment/Ecosystems</classCode>
              <classCode scheme="halDomain" n="sdv.bibs">Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Two amino acid substitutions in acetylcholinesterase 1 (AChE1), G119S and F290V, are responsible for resistance to organophosphate and carbamate insecticides in Culex pipiens mosquitoes. These mutations generate very different levels of insensitivity to insecticide inhibitors. We described here a biochemical method that rapidly identies AChE1 variants (susceptible, G119S and F290V, named S, R and V, respectively) present in individual mosquitoes. We investigated the frequency of AChE1 phenotypes in 41 eld samples collected around the Mediterranean Sea. F290V substitution was found only in 15 samples and at low frequency, whereas G119S was highly spread in all samples. However, seven V distinct alleles were identied whereas only one R allele was present. The [V] enzymatic phenotype was never observed alone, and the V allele was always found associated with the susceptible and/or G119S AChE1 ([VS], [VR] or [VRS] phenotypes). Furthermore, we showed the presence of duplicated alleles, associating a susceptible and a V copy of the ace-1 gene, in most individuals analyzed for its presence. Evolutionary forces driving the large number of F290V ace-1 alleles and their low frequency in Mediterranean countries are discussed.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-29770" status="OLD">
          <idno type="IdRef">030783291</idno>
          <idno type="ISNI">0000000121887059</idno>
          <idno type="RNSR">199511995P</idno>
          <idno type="ROR">https://ror.org/01cah1n37</idno>
          <orgName>Institut des Sciences de l'Evolution de Montpellier</orgName>
          <orgName type="acronym">UMR ISEM</orgName>
          <date type="start">1995-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Place E. Bataillon CC 064 34095 Montpellier Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.isem.univ-montp2.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR116 " active="#struct-11574" type="direct"/>
            <relation active="#struct-67872" type="direct"/>
            <relation active="#struct-110691" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5554" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-11574" status="VALID">
          <idno type="ISNI">0000000121539871</idno>
          <idno type="ROR">https://ror.org/05kpkpg04</idno>
          <orgName>Centre de Coopération Internationale en Recherche Agronomique pour le Développement</orgName>
          <orgName type="acronym">Cirad</orgName>
          <date type="start">1984-06-01</date>
          <desc>
            <address>
              <addrLine>Siège 42, rue Scheffer 75116 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cirad.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>