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Article Dans Une Revue International Journal of Biosensors & Bioelectronics Année : 2017

Implantable Microcoil for In-vivo Magnetic Resonance Spectroscopy

Résumé

Nuclear Magnetic Resonance (NMR) allows a non-destructive study of molecular structures by the measurement of their atomic nuclei magnetization. Nonetheless, NMR technique still suffers from the sensitivity weakness compared to all other spectroscopy approaches. Therefore, the optimization of detection Radio Frequency (RF) coils and the reduction of the thermal noise will lead to an increase in signal resolution particularly around the regions of interest (ROI) within the living sample. In the case of sample with limited mass and volume, the sensitivity may be improved for when the size of the RF coil matches the sample size. In this study, we developed a microcoil (500x1000μm) dedicated to the NMR micro imaging (MRI) and micro localized spectroscopy (MRS) for biomedical applications on small rodent models of human diseases. Our NMR microcoil offer a sensitivity increased by 2.5, and limits of detection (LOD) of the main cerebral metabolites estimated by MRS in-vitro measurements in good concordance with analytical values given in literature. The realization of compact sensing system based on microcoil will open the door to numerous medical and industrial.

Dates et versions

hal-01934560 , version 1 (26-11-2018)

Identifiants

Citer

Latifa Fakri-Bouchet, Mohammed Zahraoui. Implantable Microcoil for In-vivo Magnetic Resonance Spectroscopy. International Journal of Biosensors & Bioelectronics, 2017, 3 (2), pp.237 - 240. ⟨10.15406/ijbsbe.2017.03.00056⟩. ⟨hal-01934560⟩
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