We present a new model of the lithosphere and asthenosphere structure down to 300 km depth beneath the Pyrenees from the joint inversion of recent gravity and teleseismic data. Unlike previous studies, crustal correction was not applied on teleseismic data in order (i) to preserve the consistency between gravity data, which are mainly sensitive to the density structure of the crust lithosphere, and traveltime data, and (ii) to avoid the introduction of biases resulting from crustal reductions. The density model down to 100 km depth is preferentially used here to discuss the lithospheric structure of the Pyrenees, whereas the asthenospheric structure from 100 to 300 km depth is discussed from our velocity model. The absence of a high density anomaly in our model between 30 and 100 km depth (except the Labourd density anomaly) in the northern part of the Pyrenees seems to preclude eclogitization of the subducted Iberian crust at the scale of the entire Pyrenean range. Local eclogitization of the deep Pyrenean crust beneath the western part of the Axial Zone (west of Andorra) associated with the positive central density anomaly is proposed. The Pyrenean lithosphere in density and velocity models appears segmented from east to west. No clear relation between the along-strike segmentation and mapped major faults is visible in our models. The Pyrenees’ lithosphere segments are associated with different seismicity pattern in the Pyrenees suggesting a possible relation between the deep structure of the Pyrenees and its seismicity in the upper crust. The concentration of earthquakes localized just straight up the central density anomaly can reflect the subsidence and/or delamination of an eclogitized Pyrenean deep root. The velocity model in the asthenosphere is similar to previous studies. The absence of a high-velocity anomaly in the upper mantle and transition zone (i.e. 125 to 225 km depth) seems to preclude the presence of a detached oceanic lithosphere beneath the European lithosphere.