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Article Dans Une Revue Journal of the American Chemical Society Année : 2009

Preparation of 14 C-Labeled Multiwalled Carbon Nanotubes for Biodistribution Investigations

Résumé

A new method allowing the 14C-labeling of carboxylic acid functions of carbon nanotubes is described. The key step of the labeling process is a decarbonylation reaction that has been developed and optimized with the help of a screening method. The optimized process has been successfully applied to multiwalled carbon nanotubes (MWNTs), and the corresponding 14C-labeled nanotubes were used to investigate their in vivo behavior. Preliminary results obtained after i.v. contamination of rats revealed liver as the main target organ. Radiolabeling of NTs with a long-life radioactive nucleus like 14C, coupled to a highly sensitive autoradiographic method, that provides a unique detection threshold, will make it possible to determine for a long time period whether or not NTs remain in any organs after animal exposure.
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Dates et versions

hal-01930685 , version 1 (22-11-2018)

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Dominique Georgin, Bertrand Czarny, Magali Botquin, Martine Mayne-L’hermite, Mathieu Pinault, et al.. Preparation of 14 C-Labeled Multiwalled Carbon Nanotubes for Biodistribution Investigations. Journal of the American Chemical Society, 2009, 131 (41), pp.14658 - 14659. ⟨10.1021/ja906319z⟩. ⟨hal-01930685⟩
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