Genome-wide study finds a QTL with pleotropic effects on semen and production traits in Saanen goats - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2018

Genome-wide study finds a QTL with pleotropic effects on semen and production traits in Saanen goats

Résumé

Economic sustainability of dairy ruminant farms mainly relies on production, reproduction, and health of livestock. In this study, we investigated the genomic regions controlling seventeen production traits (eleven type traits, milk yield, four milk composition traits and lifespan of livestock trait), five reproduction traits (semen production and quality), and one trait related to health (Somatic Cell Score, as a proxy for mastitis resistance). Daughter yield deviation values were computed for 597 (672) Alpine and 460 (519) Saanen AI rams from Capgènes testing station for production traits, mastitis (and reproduction). For lifespan, only the oldest rams had yield deviations to allow large progeny and good accuracy, i.e. 341 Alpine and 298 Saanen. All AI rams were genotyped with the Illumina GoatSNP50 Bead Chip. We conducted genome wide association studies using polygenic mixed models and genomic relatedness matrix with the GEMMA software. The two breeds were analysed separately. Results showed a highly significant QTL on CHI 19 (22.8-28.9 Mb) in the Saanen breed for 12 of 23 studied traits. The most significant traits were udder floor position (P=7.31e-24), volume of semen production (P=8.43e-21) and protein yield (P=6.64e-17). We did not find this QTL in the Alpine breed suggesting a breed-specific control. Analyses of sequencing data of 11 Alpine and 9 Saanen rams highlighted a candidate causal mutation in the Sex Hormone Binding Globulin (SHBG) gene. We will determine whether these pleiotropic relationships are further supported by one single mutation or resolved into closely linked loci. Altogether, these results identify a major pleiotropic QTL in the Saanen breed. They will be helpful for goat selection in the future. They indicate that a within-breed genomic selection should be favoured for those traits and that including QTL information might prove useful. The study further pave the way for the addition of reproduction traits in the French goat breeding programs.
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Dates et versions

hal-01921559 , version 1 (13-11-2018)

Identifiants

  • HAL Id : hal-01921559 , version 1
  • PRODINRA : 450567

Citer

Claire Oget, Virginie Clément, Isabelle Palhiere, Gwenola Tosser-Klopp, Stéphane Fabre, et al.. Genome-wide study finds a QTL with pleotropic effects on semen and production traits in Saanen goats. 69. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2018, Dubrovnik, Croatia. Wageningen Academic Publishers, Annual Meeting of the European Association for Animal Production, 24 (1ère Ed.), 705 p., 2018, Annual Meeting of the European Association for Animal Production. ⟨hal-01921559⟩
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