Nanodiamond as a multimodal platform for drug delivery and radiosensitization of tumor cells
Résumé
Nanodiamonds (NDs) are often considered as inert platforms with high interests for biomedical applications. They are well adapted for drug delivery, and may display embedded fluorescence. We report here on a new way to consider these nanocarbon particles, by revealing therapeutic capacities coming from electronic properties of NDs. With an optimized surface chemistry, the generation of Reactive Oxygen Species (ROS) occurs when those hydrogen-terminated NDs are exposed to photon irradiation, thus opening up the field towards the radiosensitization of tumor cells.
Mots clés
multimodal platform
hydrogen
radiosensitization
zeta potential
drug delivery
Nanobioscience
Plasmas
Chemicals
Materials
Surface treatment
biochemistry
cellular effects of radiation
diamond
drug delivery systems
fluorescence
nanomedicine
nanoparticles
radiation therapy
surface chemistry
tumours
optimized surface chemistry
ND electronic properties
therapeutic capacities
nanocarbon particles
embedded fluorescence
biomedical applications
hydrogen-terminated ND
photon irradiation
ROS
Reactive Oxygen Species
tumor cell radiosensitization
nanodiamond
inert platforms