Direct torque control (DTC) has been recently used for the development of high-performance five-phase induction motor (IM) drives, where normal operation of the system has been usually considered and the ability of DTC to manage the situation has been analyzed in comparison with different rotor-field-oriented control (RFOC) strategies. The exploitation of fault-tolerant capabilities is also an interesting issue in multiphase machines, where the utility of RFOC controllers has been stated when the open-phase fault operation is considered. In this paper, the performance of DTC and RFOC controllers based on proportional resonant regulators and predictive control techniques is compared when an open-phase fault appears in a five-phase IM drive. Experimental tests are provided to compare the performance of the system using these control alternatives.