When a concrete structure is subjected to an impact, the material is subjected to high triaxial compressive stresses. Furthermore, the water saturation ratio in massive concrete structures may reach nearly 100% at the core, whereas the material dries quickly on the skin. The impact response of a massive concrete wall may thus depend on the state of water saturation in the material. This paper presents some triaxial tests performed at a maximum confining pressure of 600 MPa on concrete representative of a nuclear power plant containment building. Experimental results show the concrete constitutive behavior and its dependence on the water saturation ratio. It is observed that as the degree of saturation increases, a decrease in the volumetric strains as well as in the shear strength is observed. The coupled PRM constitutive model does not accurately reproduce the response of concrete specimens observed during the test. The differences between experimental and numerical results can be explained by both the influence of the saturation state of concrete and the effect of deviatoric stresses, which are not accurately taken into account. The PRM model was modified in order to improve the numerical prediction of concrete behavior under high stresses at various saturation states.