We use the Isospin Quantum Molecular Dynamics model (IQMD) to analyze the centrality dependence of the isospin ratio of pions, $\pi^-/\pi^+$. We find that the density dependence of the asymmetry potential, the Pauli blocking of the $\Delta$-decay and the thickness of the neutron skin influence in different ways this observable. Using the centrality dependence of this ratio at different beam energies we can disentangle the different contributions and open the way for their experimental determination.