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Article Dans Une Revue Developmental and Comparative Immunology Année : 2018

In silico analysis of Schmidtea mediterranea TIR domain-containing proteins

Landry Laure Tsoumtsa
  • Fonction : Auteur
Seynabou Sougoufora
  • Fonction : Auteur
Cedric Torre
  • Fonction : Auteur
Emmanuel Lemichez
  • Fonction : Auteur
Eric Ghigo
  • Fonction : Auteur

Résumé

While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolution in metazoan. We report the presence of twenty proteins containing between one and two TIR domains. In addition, our phylogenetic-based reconstruction approach identified Smed-SARM and Smed-MyD88 as conserved TLR adaptors. (C) 2018 Elsevier Ltd. All rights reserved.
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Dates et versions

hal-01858942 , version 1 (21-08-2018)

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Landry Laure Tsoumtsa, Seynabou Sougoufora, Cedric Torre, Emmanuel Lemichez, Pierre Pontarotti, et al.. In silico analysis of Schmidtea mediterranea TIR domain-containing proteins. Developmental and Comparative Immunology, 2018, 86, pp.214-218. ⟨10.1016/j.dci.2018.05.004⟩. ⟨hal-01858942⟩

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