We present an analysis of decadal in situ and remote sensing observations of water vapor over the Cézeaux and puy de Dôme, located in central France (45 • N, 3 • E), in order to document the variability, cycles and trends of surface and tropospheric water vapor at different time scales and the geophysical processes responsible for the water vapor distributions. We use meteorological stations, GPS (Global Positioning System), and lidar datasets, supplemented with three remote sources of water vapor (COSMIC-radio-occultation, ERA-interim-ECMWF numerical model, and AIRS-satellite). The annual cycle of water vapor is clearly established for the two sites of different altitudes and for all types of measurement. Cezeaux and puy de Dôme present almost no diurnal cycle, suggesting that the variability of surface water vapor at this site is more influenced by a sporadic meteorological system than by regular diurnal variations. The lidar dataset shows a greater monthly variability of the vertical distribution than the COSMIC and AIRS satellite products. The Cézeaux site presents a positive trend for the GPS water vapor total column (0.42 ± 0.45 g·kg −1 /decade during 2006-2017) and a significant negative trend for the surface water vapor mixing ratio (−0.16 ± 0.09 mm/decade during 2002-2017). The multi-linear regression analysis shows that continental forcings (East Atlantic Pattern and East Atlantic-West Russia Pattern) have a greater influence than oceanic forcing (North Atlantic Oscillation) on the water vapor variations.