This paper is concerned with a topological asymptotic expansion for a parabolic operator. We consider the three dimensional non-stationary Stokes system as a model problem and we derive a sensitivity analysis with respect to the creation of a small Dirich-let geometric perturbation. The established asymptotic expansion valid for a large class of shape functions. The proposed analysis is based on a preliminary estimate describing the velocity field perturbation caused by the presence of a small obstacle in the fluid flow domain. The obtained theoretical results are used to built a fast and accurate detection algorithm. Some numerical examples issued from a lake oxygenation problem show the efficiency of the proposed approach.