The 4πγ-counting technique is recognized as a powerful primary method for the standardization of radionuclides decaying with abundant gamma emissions. Based on the use of a gamma detector in quasi 4π-geometry, a detection efficiency close to 100% and a low uncertainty can be achieved thanks to the summing effect of subsequent gamma transitions. Uncertainties have to be assigned to the realistic modelling of the source–detector geometry with respect to dimensions, density and material composition, the calculation of the total counting efficiency of the detector for the various emitted radiation, and the effect of possible flaws in the decay scheme of a radionuclide on the calculated total efficiency. Other uncertainty factors pertain to typical metrological sources of uncertainty, such as weighing, nuclear counting with pulse pile-up and system dead-time effects, impurity corrections, decay corrections, timing and frequency, etc. In order to ensure good metrological practices at NMIs, the uncertainties particular to the method are discussed.