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                <title xml:lang="en">Screening of ZnT8 autoantibodies in the diagnosis of autoimmune diabetes in a large French cohort</title>
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                <term xml:lang="en"> glutamic-acid decarboxylase</term>
                <term xml:lang="en">Anti-GAD autoantibodies</term>
                <term xml:lang="en"> Anti-IA-2</term>
                <term xml:lang="en"> Anti-ZnT8 autoantibodies</term>
                <term xml:lang="en"> autoantibodies autoimmune diabetes</term>
                <term xml:lang="en"> autoantigen</term>
                <term xml:lang="en"> children</term>
                <term xml:lang="en"> islet-cell antibodies</term>
                <term xml:lang="en"> identification</term>
                <term xml:lang="en"> zinc transporter 8</term>
                <term xml:lang="en"> type-1</term>
                <term xml:lang="en"> Type 1 diabetes</term>
                <term xml:lang="en"> prediction</term>
                <term xml:lang="en"> onset</term>
                <term xml:lang="en"> mellitus</term>
                <term xml:lang="en"> Medical Laboratory Technology</term>
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              <p>Aim of the study: Evaluate the added value of screening anti-ZnT8 antibodies (ZnT8A) in addition to the classical anti-GAD (GADA) and anti-IA-2 (IA-2A) antibodies for the diagnosis of type-1 diabetes (T1D) within a large cohort of both children and adults. Materials and methods: Retrospective 2-year study including 516 patients (215 children, 301 adults) who had blood tests at diabetes onset and/or for diabetes classification. ZnT8A, GADA, and IA-2A were analyzed in all samples. Results: Among those individuals included, 142 (28%) were ZnT8A-positive. A total of 228/516 suffered from T1D, of whom 110 (48%) were ZnT8A-positive and 166 (73%) GADA and/or IA-2A positive. When adding ZnT8A to GADA/IA-2A, 184 (81%) patients were positive for \textgreater= 1 Ab. Regarding the 122 patients at T1D onset, 75 (61%) were positive for ZnT8A and the proportion of patients with T1D with \textgreater= 1 Ab reached 89%. The highest prevalence of ZnT8A was observed in children aged 6-10 years. Fourteen of the 124 patients positive for ZnT8A with a known clinical diagnosis suffered from a disease other than T1D. Conclusions: ZnT8A should be included in routine evaluation at diabetes onset and is a valuable biological marker to classify newly-diagnosed diabetics. The predictive value in our high-risk subjects has to be confirmed.</p>
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