<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01847400</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T03:03:25+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders</title>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Haution-Bitker</surname>
              </persName>
              <idno type="halauthorid">1403115-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">T.</forename>
                <surname>Gilbert</surname>
              </persName>
              <idno type="halauthorid">375599-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Vignoles</surname>
              </persName>
              <idno type="halauthorid">862733-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Lecardonnel</surname>
              </persName>
              <idno type="halauthorid">1403116-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Watelet</surname>
              </persName>
              <idno type="halauthorid">1403117-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emilie</forename>
                <surname>Blond</surname>
              </persName>
              <idno type="halauthorid">923478-0</idno>
              <affiliation ref="#struct-139835"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Drai</surname>
              </persName>
              <idno type="halauthorid">423137-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Bonnefoy</surname>
              </persName>
              <idno type="halauthorid">615468-0</idno>
              <affiliation ref="#struct-139835"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Lauriane</forename>
                <surname>Pillet</surname>
              </persName>
              <email type="md5">af3bd2523de26bc80622671e8010a22b</email>
              <email type="domain">univ-lyon1.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-07-23 15:05:54</date>
              <date type="whenModified">2025-03-21 15:12:20</date>
              <date type="whenReleased">2018-07-23 15:05:54</date>
              <date type="whenProduced">2018-06</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="511378">
                <persName>
                  <forename>Lauriane</forename>
                  <surname>Pillet</surname>
                </persName>
                <email type="md5">af3bd2523de26bc80622671e8010a22b</email>
                <email type="domain">univ-lyon1.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01847400</idno>
            <idno type="halUri">https://hal.science/hal-01847400</idno>
            <idno type="halBibtex">hautionbitker:hal-01847400</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Nutrition, Health &amp; Aging&lt;/i&gt;, 2018, 22 (6), pp.718-725. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s12603-018-1010-z"&gt;&amp;#x27E8;10.1007/s12603-018-1010-z&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Nutrition, Health &amp; Aging, 2018, 22 (6), pp.718-725. &amp;#x27E8;10.1007/s12603-018-1010-z&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INSA-LYON">Institut National des Sciences Appliquées de Lyon</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="CARMEN" corresp="INSERM">Cardiovasculaire, Métabolisme, Diabétologie et Nutrition</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders</title>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Haution-Bitker</surname>
                  </persName>
                  <idno type="halauthorid">1403115-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">T.</forename>
                    <surname>Gilbert</surname>
                  </persName>
                  <idno type="halauthorid">375599-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Vignoles</surname>
                  </persName>
                  <idno type="halauthorid">862733-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Lecardonnel</surname>
                  </persName>
                  <idno type="halauthorid">1403116-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Watelet</surname>
                  </persName>
                  <idno type="halauthorid">1403117-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emilie</forename>
                    <surname>Blond</surname>
                  </persName>
                  <idno type="halauthorid">923478-0</idno>
                  <affiliation ref="#struct-139835"/>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Drai</surname>
                  </persName>
                  <idno type="halauthorid">423137-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Bonnefoy</surname>
                  </persName>
                  <idno type="halauthorid">615468-0</idno>
                  <affiliation ref="#struct-139835"/>
                  <affiliation ref="#struct-353860"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21863</idno>
                <idno type="issn">1279-7707</idno>
                <idno type="eissn">1760-4788</idno>
                <title level="j">Journal of Nutrition, Health &amp; Aging</title>
                <imprint>
                  <publisher>Springer Verlag (Germany)</publisher>
                  <biblScope unit="volume">22</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">718-725</biblScope>
                  <date type="datePub">2018-06</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s12603-018-1010-z</idno>
              <ref target="http://link.springer.com/10.1007/s12603-018-1010-z" type="seeAlso"/>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">fatty acids</term>
                <term xml:lang="en">Nutrition &amp; Dietetics</term>
                <term xml:lang="en">alzheimers-disease</term>
                <term xml:lang="en">biomarkers</term>
                <term xml:lang="en">Geriatrics &amp; Gerontology</term>
                <term xml:lang="en">older-adults</term>
                <term xml:lang="en">risk</term>
                <term xml:lang="en">blood</term>
                <term xml:lang="en">adipose-tissue</term>
                <term xml:lang="en">impairment</term>
                <term xml:lang="en">performance</term>
                <term xml:lang="en">omega-3-fatty-acids</term>
                <term xml:lang="en">neurocognitive disorders</term>
                <term xml:lang="en">n-3</term>
                <term xml:lang="en">erythrocytes membrane</term>
                <term xml:lang="en">Dementia</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>To examine the association of plasmatic and erythrocyte concentrations polyunsaturated fatty acids (PUFA) with both cognitive status and decline. Longitudinal observational cohort study. Setting: Memory Clinic of Lyon Sud university hospital. 140 patients, aged 60 and older, were referred to the memory clinic, and successively included in the cohort, between March 2010 and February 2014. Concentration of omega-3 PUFA (eicosapentaenoic: EPA and docosahexaenoic: DHA) and omega-6 PUFA (arachidonic: AA), were measured at baseline in plasma and in the erythrocytes membrane. Cognitive status was assessed using the mini mental state examination (MMSE), at baseline and every six months during follow-up. The median follow-up period was of 11,5 months. Compared to participants with minor neurocognitive disorders (MMSEae24), participants with major neurocognitive disorders (NCD) had lower plasmatic concentrations of EPA and DHA (p \textless 0.05) at baseline. Erythrocyte AA and DHA concentrations were significantly lower in patients with cognitive decline (defined as a ae2 points loss of MMSE per year), while no difference in plasmatic concentrations was observed. Our study suggests that omega-3 PUFA plasma concentrations (mainly EPA and DHA) could be associated with cognitive status in older people. Moreover, in this exploratory study, lower erythrocyte PUFA concentrations (AA and DHA) were associated with accelerated decline and could be proposed as a surrogate marker for prediction of cognitive decline.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-139835" status="OLD">
          <idno type="IdRef">149700210</idno>
          <idno type="RNSR">201119381Y</idno>
          <orgName>Cardiovasculaire, métabolisme, diabétologie et nutrition</orgName>
          <orgName type="acronym">CarMeN</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Lyon Sud - BP 12 - 165 Chemin du Grand Revoyet - 69921 Oullins cedex INSA, Bât. IMBL, La Doua - 11 Avenue Jean Capelle - 69621 Villeurbanne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://carmen.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR1397" active="#struct-92114" type="direct"/>
            <relation name="UM92" active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300074" type="direct"/>
            <relation name="U1060" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-219748" status="VALID">
          <idno type="IdRef">052444724</idno>
          <idno type="ISNI">0000 0001 2292 0228</idno>
          <orgName>Institut National des Sciences Appliquées de Lyon</orgName>
          <orgName type="acronym">INSA Lyon</orgName>
          <date type="start">1957-03-18</date>
          <desc>
            <address>
              <addrLine>20 Avenue Albert Einstein, 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>