Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood - Archive ouverte HAL Access content directly
Journal Articles Journal of Comparative Neurology Year : 2016

Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood

(1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1)
1

Abstract

Early-born g-aminobutyric acid (GABA) neurons (EBGNs) are major components of the hippocampal circuit because at early postnatal stages they form a subpopu-lation of " hub cells " transiently supporting CA3 network synchronization (Picardo et al. [2011] Neuron 71:695– 709). It is therefore essential to determine when these cells acquire the remarkable morphofunctional attributes supporting their network function and whether they develop into a specific subtype of interneuron into adulthood. Inducible genetic fate mapping conveniently allows for the labeling of EBGNs throughout their life. EBGNs were first analyzed during the perinatal week. We observed that EBGNs acquired mature characteristics at the time when the first synapse-driven synchronous activities appeared in the form of giant depolarizing potentials. The fate of EBGNs was next analyzed in the adult hippocampus by using anatomical characterization. Adult EBGNs included a significant proportion of cells projecting selectively to the septum; in turn, EBGNs were targeted by septal and entorhinal inputs. In addition, most EBGNs were strongly targeted by cholinergic and monoaminergic terminals, suggesting significant subcortical innervation. Finally, we found that some EBGNs located in the septum or the entorhi-nal cortex also displayed a long-range projection that we traced to the hippocampus. Therefore, this study shows that the maturation of the morphophysiological properties of EBGNs mirrors the evolution of early network dynamics, suggesting that both phenomena may be causally linked. We propose that a subpopulation of EBGNs forms into adulthood a scaffold of GABAergic projection neurons linking the hippocampus to distant structures.
Fichier principal
Vignette du fichier
Villette_2016_JCN_Baude Development of early born gamma aminobutyric acid hub neurons in Mouse hippocampus from embryogenesis to adulthood.pdf (4.31 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-01847021 , version 1 (23-07-2018)

Identifiers

Cite

Vincent Villette, Philippe Guigue, Michel Aim, Vitor Hugo Sousa, Erwan Leprince, et al.. Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood. Journal of Comparative Neurology, 2016, 524 (12), pp.2440-2461. ⟨10.1002/cne.23961⟩. ⟨hal-01847021⟩
75 View
37 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More