The overall dependability of an interactive system is one of its weakest components, which is usually its user interface. The presented approach integrates techniques from the dependable computing field and elements of the user-centered design. Risk analysis and fault-tolerance techniques are used in combination with task analysis and modeling to describe and analyze the impact of system faults on human activities and the impact of human deviation or errors on system performance and overall mission performance. A technique for systematic analysis of human errors, effects, and criticality (HEECA) is proposed. It is inspired and adapted from the Failure Mode, Effects, and Criticality Analysis technique. The key points of the approach are: 1) the HEECA technique combining a systematic analysis of the effects of system faults and of human errors; and 2) a task modeling notation to describe and to assess the impact of system faults and human errors on operators' activities and system performance. These key points are illustrated on an example extracted from a case study of the space domain. It demonstrates the feasibility of this approach as well as its benefits in terms of identifying opportunities for redesigning the system, redesigning the operations, and for modifying operators' training.