A new microsystem, designed to detect and measure in real time the enthalpy of mixing of two fluid-constituents is presented. A preliminary approach to arrange miniaturized batch-cells allowing detecting enthalpy of dilution or mixing is first discussed. Then, a coherent rationale leading to structure devices operating in real time is formulated, considering the straightforward assessment of heat flux transducers (HFTs) capability. Basic thermodynamic observations regarding analogy between thermal and electrical systems are highlighted prior consideration of practical examples involving mixing of water and alcohols. Fundamentals about HFTs design are highlighted before presenting an adequate way to integrate both functions of mixing and measuring the entailed heat exchange as two continuously flowing fluids interact with each other. Then, a prototype of such a dedicated device is discussed with its relevant expected performance.