Article Dans Une Revue Advances in Experimental Medicine and Biology Année : 2017

The Role of Estrogens in Pancreatic Islet Physiopathology

Résumé

In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity, and apoptosis. Three estrogen receptors (ERs)-ERα, ERβ, and the G protein-coupled ER (GPER)-have been identified in rodent and human β-cells. This chapter describes recent advances in our understanding of the role of ERs in islet β-cell function, nutrient homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how ERs represent potential therapeutic targets for the maintenance of functional β-cell mass.
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Dates et versions

hal-01833109 , version 1 (09-07-2018)

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Citer

Franck Mauvais-Jarvis, Cedric Le May, Joseph P. Tiano, Suhuan Liu, Gamze Kilic-Berkmen, et al.. The Role of Estrogens in Pancreatic Islet Physiopathology. Advances in Experimental Medicine and Biology, 2017, Equipe IV, 1043, pp.385--399. ⟨10.1007/978-3-319-70178-3_18⟩. ⟨hal-01833109⟩
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