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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2015

Fluorinated hydroxypiperidines as selective β-glucosidase inhibitors

Résumé

A new series of fluoroallylamines derived from hydroxypiperidines was prepared and evaluated against various glycosidases. The short synthesis of target molecules involved the modified Julia reaction between aldehydes and functionalized fluoroaminosulfones. Biological studies revealed good and selective β-glucosidase inhibition in the micromolar range for two compounds, while the non-fluorinated analogue of the most active compound was selective towards α-glucosidase.

Domaines

Chimie organique
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Dates et versions

hal-01829637 , version 1 (04-07-2018)

Identifiants

Citer

Clothilde Le Guen, Teresa Mena-Barragán, Carmen Ortiz Mellet, David Gueyrard, Emmanuel Pfund, et al.. Fluorinated hydroxypiperidines as selective β-glucosidase inhibitors. Organic & Biomolecular Chemistry, 2015, 13 (21), pp.5983 - 5996. ⟨10.1039/C5OB00721F⟩. ⟨hal-01829637⟩
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