The effects of two plastic-derived chemicals: Bisphenol A (BPA) and di-2-ethylhexyl phthalate (DEHP) were assessed on abundance and physiological responses of the marine toxic dinoflagellate Alexandrim pacificum. During 7 days experiment, A. pacificum was exposed to different levels of BPA and DEHP (separately and in mixture). The responses were evaluated and compared with controls. Results showed that A. pacificum was highly sensitive to this contaminants comparing to other phytoplankton species. BPA and DEHP caused the decrease of the biomass (1.2 to 50 times lower relative to the controls), as well as the perturbation of the photosystem and the photosynthetic activity. Nevertheless, our results show a recovery of contaminated cells activity depending on exposure time and BPA and DEHP contamination. This could be related to an adaptation to induced stress or a degradation of BPA and DEHP in the medium.