Testing methods have been developed to compare the mechanical responses and failure behavior of polyether-ether-keton (PEEK) thermoplastic polymer; under quasi-static, high strain rate tensile tests and fatigue loading. Tensile tests were performed with the strain rates varying from 0.0003 s−1 to 60 s−1 and at different temperatures to compare the flow characteristics of the samples undergone various testing conditions. Fatigue tests at different amplitudes and frequencies were also performed to evaluate the temperature rise during cyclic loading and its effect on the fracture behavior. Results show that dynamic tension, in comparison with quasi-static behavior, causes brittle fracture; whereas under fatigue test at high frequencies and loading amplitudes the material behaves not only a more ductile behavior but also it clearly shows the influences of induced self-heating in the modulus and mechanical properties of the PEEK were significant. So the major aim of this article is to discuss about the induced temperature and its effect on the fracture surface. Thermal fatigue has a very significant role in increasing temperature and reducing fatigue life; from there it is necessary to know the conditions at which thermal fatigue happens and also the amount of energy which is consumed. Obtained equation from the experimental results and calculations can estimate the energy dissipation in the fatigue tests which is as a function of cycle and frequency.