Mechanically induced development and maturation of human intestinal organoids in vivo
Résumé
The natural ability of stem cells to self-organize into functional tissue has been harnessed for the production of functional human intestinal organoids. Although dynamic mechanical forces play a Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms * Correspondence and requests for materials should be addressed to Maxime M. Mahe: maxime.mahe@cchmc.org. + previous affiliation Author Contributions H.M.P. and M.M.M. conceived and designed the study; H.M.P., D.W., T.A.H., M.A.H., and M.M.M. performed experiments and collected data; N.B. generated HIOs; N. H. and J.C.Y.D. manufactured springs; H.M.P., D.W., S.C., and M.M.M. analyzed data; H.M.P., M.B., S.P.H., J.M.W., M.A.H., and M.M.M. interpreted experimental findings; H.M.P. and M.M.M. prepared figures and drafted manuscript; H.M.P., S.P.H., J.M.W., M.A.H., and M.M.M. made critical revisions to the manuscript; all authors approved the manuscript's final version.
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