Simulating gas-liquid flows involving a wide range of spatial and temporal scales and multiple topological changes remains a major challenge nowadays, as the computational cost associated with direct numeri- cal simulation still makes this approach unaffordable. A common alternative is the two-fluid Euler–Euler formulation that avoids solving all scales at the price of semi-empirical closures of mass, momentum and energy exchanges between the two fluids. Many of such closures are available but their performances in complex flows are still in debate. Closures considering separately large gas structures and smaller bub- bles and making these two populations evolve and possibly exchange mass according to their interac- tions with the surrounding liquid have recently been proposed. In order to assess the validity of some of these closures, we carry out an original experiment in a simple configuration exhibiting a rich succes- sion of hydrodynamic events, namely the emptying of a water bottle. We simulate this experiment with the NEPTUNE_CFD code, using three different closure approaches aimed at modelling interfacial momen- tum exchanges with various degrees of complexity. Based on experimental results, we perform a detailed analysis of global and local flow characteristics predicted by each approach to unveil its potentialities and shortcomings. Although all of them are found to predict correctly the overall features of the emp- tying process, striking differences are observed regarding the distribution of the dispersed phase and its consequences in terms of liquid entrainment.