α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities - Archive ouverte HAL Access content directly
Journal Articles Journal of Biological Chemistry Year : 2011

α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities

Abstract

Background: Raffinose, an abundant carbohydrate in plants, is degraded into galactose and sucrose by intestinal microbial enzymes. Results: AgaSK is a protein coupling galactosidase and sucrose kinase activity. The structure of the galactosidase domain sheds light onto substrate recognition. Conclusion: AgaSK produces sucrose-6-phosphate directly from raffinose. Significance: Production of sucrose-6-phosphate directly from raffinose points toward a novel glycolytic pathway in bacteria.
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hal-01793279 , version 1 (16-05-2018)

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Laëtitia Bruel, Gerlind Sulzenbacher, Marine Cervera Tison, Ange Pujol, Cendrine Nicoletti, et al.. α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities. Journal of Biological Chemistry, 2011, 286 (47), pp.40814 - 40823. ⟨10.1074/jbc.M111.286039⟩. ⟨hal-01793279⟩
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