Alzheimer culprits: cellular crossroads and interplay - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cellular Signalling Année : 2012

Alzheimer culprits: cellular crossroads and interplay

Résumé

Alzheimer's disease (AD) is the primary cause of dementia in the elderly and one of the major health problems worldwide. Since its first description by Alois Alzheimer in 1907, noticeable but insufficient scientific comprehension of this complex pathology have been achieved. All the research that has been pursued takes origin from the identification of the pathological hallmarks in the forms of amyloid-b (Ab) deposits (plaques), and aggregated hyperphosphorylated tau protein filaments (named neurofibrillary tangles). Since this discovery, many hypotheses have been proposed to explain the origin of the pathology. The "amyloid cascade hypothesis" is the most accredited theory. The mechanism suggested to be one of the initial causes of AD is an imbalance between the production and the clearance of Ab peptides. Therefore, Amyloid Precursor Protein (APP) synthesis, trafficking and metabolism producing either the toxic Ab peptide via the amyloidogenic pathway or the sAPPa fragment via the non amyloidogenic pathway have become appealing subjects of study. Being able to reduce the formation of the toxic Ab peptides is obviously an immediate approach in the trial to prevent AD. The following review summarizes the most relevant discoveries in the field of the last decades.
Fichier principal
Vignette du fichier
2012 Cell Sign Claeysen.pdf (1.55 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01792371 , version 1 (19-02-2020)

Identifiants

Citer

Sylvie Claeysen, Maud Cochet-Bissuel, Romain Donneger, Aline Dumuis, Joël Bockaert, et al.. Alzheimer culprits: cellular crossroads and interplay. Cellular Signalling, 2012, 24 (9), pp.1831-1840. ⟨10.1016/j.cellsig.2012.05.008⟩. ⟨hal-01792371⟩
82 Consultations
202 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More