<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01784365</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-04-30T06:04:42+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Anaesthetic hypersensitivity reactions in France between 2011 and 2012: the 10th GERAP epidemiologic survey</title>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Tacquard</surname>
              </persName>
              <idno type="halauthorid">183614-0</idno>
              <affiliation ref="#struct-300149"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">O.</forename>
                <surname>Collange</surname>
              </persName>
              <email type="md5">49ff5e0da3e74ab63eae73f9cf39490b</email>
              <email type="domain">unistra.fr</email>
              <idno type="idhal" notation="numeric">1102511</idno>
              <idno type="halauthorid" notation="string">1362617-1102511</idno>
              <idno type="IDREF">https://www.idref.fr/067354726</idno>
              <affiliation ref="#struct-300149"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Gomis</surname>
              </persName>
              <idno type="halauthorid">1023306-0</idno>
              <affiliation ref="#struct-50021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.-M.</forename>
                <surname>Malinovsky</surname>
              </persName>
              <idno type="halauthorid">1362618-0</idno>
              <affiliation ref="#struct-50021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">N.</forename>
                <surname>Petitpain</surname>
              </persName>
              <idno type="halauthorid">532200-0</idno>
              <affiliation ref="#struct-300157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Demoly</surname>
              </persName>
              <email type="md5">23f02926435bb7bfb08293ddfbbdc588</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">pascal-demoly</idno>
              <idno type="idhal" notation="numeric">754222</idno>
              <idno type="halauthorid" notation="string">410632-754222</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/Y-9938-2019</idno>
              <idno type="IDREF">https://www.idref.fr/03442959X</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7827-7964</idno>
              <idno type="GOOGLE SCHOLAR">http://scholar.google.fr/citations?user=So_kniIAAAAJ&amp;hl=fr</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Y-9938-2019</idno>
              <affiliation ref="#struct-81964"/>
              <affiliation ref="#struct-267618"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Nicoll</surname>
              </persName>
              <idno type="halauthorid">1362619-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Mertes</surname>
              </persName>
              <idno type="halauthorid">1307298-0</idno>
              <affiliation ref="#struct-300149"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Anthony</forename>
                <surname>Herrada</surname>
              </persName>
              <email type="md5">fcb22fb3703cf470da2926a2fd72f58a</email>
              <email type="domain">unimes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-05-03 13:51:20</date>
              <date type="whenModified">2026-02-07 05:14:57</date>
              <date type="whenReleased">2018-05-03 13:51:20</date>
              <date type="whenProduced">2017-03</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="557504">
                <persName>
                  <forename>Anthony</forename>
                  <surname>Herrada</surname>
                </persName>
                <email type="md5">fcb22fb3703cf470da2926a2fd72f58a</email>
                <email type="domain">unimes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01784365</idno>
            <idno type="halUri">https://hal.science/hal-01784365</idno>
            <idno type="halBibtex">tacquard:hal-01784365</idno>
            <idno type="halRefHtml">&lt;i&gt;Acta Anaesthesiologica Scandinavica Supplementum&lt;/i&gt;, 2017, 61 (3), pp.290 - 299. &lt;a target="_blank" href="https://dx.doi.org/10.1111/aas.12855"&gt;&amp;#x27E8;10.1111/aas.12855&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Acta Anaesthesiologica Scandinavica Supplementum, 2017, 61 (3), pp.290 - 299. &amp;#x27E8;10.1111/aas.12855&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="IPLESP" corresp="SORBONNE-UNIVERSITE">Institut Pierre Louis d'Epidémiologie et de Santé Publique</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Anaesthetic hypersensitivity reactions in France between 2011 and 2012: the 10th GERAP epidemiologic survey</title>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Tacquard</surname>
                  </persName>
                  <idno type="halauthorid">183614-0</idno>
                  <affiliation ref="#struct-300149"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">O.</forename>
                    <surname>Collange</surname>
                  </persName>
                  <email type="md5">49ff5e0da3e74ab63eae73f9cf39490b</email>
                  <email type="domain">unistra.fr</email>
                  <idno type="idhal" notation="numeric">1102511</idno>
                  <idno type="halauthorid" notation="string">1362617-1102511</idno>
                  <idno type="IDREF">https://www.idref.fr/067354726</idno>
                  <affiliation ref="#struct-300149"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Gomis</surname>
                  </persName>
                  <idno type="halauthorid">1023306-0</idno>
                  <affiliation ref="#struct-50021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.-M.</forename>
                    <surname>Malinovsky</surname>
                  </persName>
                  <idno type="halauthorid">1362618-0</idno>
                  <affiliation ref="#struct-50021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">N.</forename>
                    <surname>Petitpain</surname>
                  </persName>
                  <idno type="halauthorid">532200-0</idno>
                  <affiliation ref="#struct-300157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Demoly</surname>
                  </persName>
                  <email type="md5">23f02926435bb7bfb08293ddfbbdc588</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">pascal-demoly</idno>
                  <idno type="idhal" notation="numeric">754222</idno>
                  <idno type="halauthorid" notation="string">410632-754222</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/Y-9938-2019</idno>
                  <idno type="IDREF">https://www.idref.fr/03442959X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7827-7964</idno>
                  <idno type="GOOGLE SCHOLAR">http://scholar.google.fr/citations?user=So_kniIAAAAJ&amp;hl=fr</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Y-9938-2019</idno>
                  <affiliation ref="#struct-81964"/>
                  <affiliation ref="#struct-267618"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Nicoll</surname>
                  </persName>
                  <idno type="halauthorid">1362619-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Mertes</surname>
                  </persName>
                  <idno type="halauthorid">1307298-0</idno>
                  <affiliation ref="#struct-300149"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22862</idno>
                <idno type="issn">0515-2720</idno>
                <title level="j">Acta Anaesthesiologica Scandinavica Supplementum</title>
                <imprint>
                  <publisher>Wiley-Blackwell</publisher>
                  <biblScope unit="volume">61</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">290 - 299</biblScope>
                  <date type="datePub">2017-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1111/aas.12855</idno>
              <idno type="pubmed">28164269</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND:Immediate hypersensitivity reactions during anaesthesia are rare but potentially life-threatening. The epidemiology changes with time and evolving professional practice, and hence needs to be monitored. Our objective was to follow this epidemiology.METHODS:This was a retrospective, observational study in French hospital clinics, conducted by GERAP members (Groupe d'Étude des Réactions Anaphylactoïdes Périopératoires). Consecutive patients seen in allergo-anaesthesia outpatient clinics, who had experienced a hypersensitivity reaction during anaesthesia between 1 January 2011 and 31 December 2012, were included. Demographic data, allergy history, drugs received before the reaction, symptoms of the reaction, results of blood samples (histamine, tryptase, IgE-specific assays), and results of the allergy assessment were recorded.RESULTS:The most common causes of allergic reactions were (Neuromuscular Blocking Agents) NMBAs (N = 302; 60.6%), antibiotics (N = 91, 18.2%, Cephalosporin N = 49, 10%) and dyes (N = 27; 5.4%). Latex as an allergic agent was involved in 26 cases (5.2%), hypnotics in 11 cases (2.2%) and opioids in seven cases (1.4%). Of the NMBAs, Rocuronium had the highest proportion of reactions (13.8 reactions/100,000 vials sold) followed by Suxamethonium (13.3/100,000 vials sold). Cisatracurium had the lowest proportion of reactions (0.4/100,000 vials sold). Patients were sensitized to two or more NMBAs in 48.9% of cases and without testing, cross-sensitivity cannot be predicted.CONCLUSIONS:When compared with the previous GERAP studies, NMBAs are still the most frequently triggering allergens, with marked differences between individual NMBAs, but they are now followed by antibiotics (of which greater than 50% were cephalosporins) and dyes. Anaesthetists must be aware of the differences between drugs and of the pattern of emerging allergens. For the future of safe anaesthesia, allergy assessment is essential.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-300149" status="VALID">
          <orgName>Centre Hospitalier Universitaire [Strasbourg]</orgName>
          <orgName type="acronym">CHU Strasbourg</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-211628" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-50021" status="VALID">
          <orgName>Hôpital Maison Blanche</orgName>
          <desc>
            <address>
              <addrLine>45 rue Cognacq Jay ; 51100 Reims</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-417765" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-81964" status="VALID">
          <orgName>Département pneumologie et addictologie [Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>371, av. du Doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300143" type="direct"/>
            <relation active="#struct-258773" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-267618" status="OLD">
          <idno type="RNSR">201420917E</idno>
          <orgName>Institut Pierre Louis d'Epidémiologie et de Santé Publique</orgName>
          <orgName type="acronym">iPLESP</orgName>
          <desc>
            <address>
              <addrLine>56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iplesp.upmc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93591" type="direct"/>
            <relation name="U1136" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-211628" status="VALID">
          <idno type="IdRef">030378842</idno>
          <idno type="ROR">https://ror.org/04bckew43</idno>
          <orgName>Hôpitaux Universitaires de Strasbourg</orgName>
          <orgName type="acronym">HUS</orgName>
          <desc>
            <address>
              <addrLine>1 place de l'hôpital BP 426 67091 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chru-strasbourg.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-417765" status="VALID">
          <orgName>Hôpital universitaire Robert Debré [Reims]</orgName>
          <orgName type="acronym">CHU Reims</orgName>
          <desc>
            <address>
              <addrLine>rue du General Koenig 51090 Reims Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-reims.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300143" status="VALID">
          <idno type="ISNI">000000010507738X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Hôpital Arnaud de Villeneuve [CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>371 avenue du Doyen Gaston Giraud - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/decouvrir/etablissements/arnaud-de-villeneuve</ref>
          </desc>
          <listRelation>
            <relation active="#struct-258773" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-258773" status="VALID">
          <idno type="ISNI">000000009961060X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
          <desc>
            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-93591" status="OLD">
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.upmc.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>