Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Physiology and Biochemistry Année : 2018

Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients

Frédéric Capel
Dominique Dardevet
Jérémie David
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Corinne Pouyet
Sergio Polakof
Laurent Mosoni

Résumé

High-sugar intake and senescence share common deleterious effects, in particular in liver, but combination of these two factors was little studied. Our aims were to examine the effect of a high-sucrose diet in liver of old rats and also the potential benefices of a polyphenol/micronutrient supplementation. Four groups of 22-month-old male rats fed during 5 months with a diet containing either 13 or 62% sucrose, supplemented or not with rutin, vitamin E, A, D, selenium, and zinc were compared. We measured liver macronutrient composition, glycation/oxidative stress, enzyme activities (lipogenesis, β-oxidation, fructokinase), gene expression (enzymes and transcription factors), in vivo protein synthesis rates and plasma parameters. Sucrose induced an increase in plasma and liver lipid content, and a stimulation of liver protein synthesis rates. Gene expression was little changed by sucrose, with lower levels for LXR-α and LXR-β. Polyphenol/micronutrient supplementation tended to limit liver triglyceride infiltration through variations in fatty acid synthase, acyl coA oxidase, and possibly ATP-citrate lyase activities. In conclusion, despite differences in enzymatic regulations, and blunted responses of gene expression, high-sucrose diet was still able to induce a marked increase in liver lipid content in old animals. However, it probably attenuated the positive impact of polyphenol/micronutrients.
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Dates et versions

hal-01769296 , version 1 (17-04-2018)

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Eva Gatineau, Frédéric Capel, Dominique Dardevet, Jérémie David, Corinne Pouyet, et al.. Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. Journal of Physiology and Biochemistry, 2018, 74 (4), 9 p. ⟨10.1007/s13105-018-0628-y⟩. ⟨hal-01769296⟩
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