We propose a site-classification scheme based on the predominant period of the site, as determined from the average horizontal-to-vertical (H/V) spectral ratios of ground motion. Our scheme extends Zhao et al. (2006) classifications by adding two classes, the most important of which is defined by flat H/V ratios with amplitudes less than 2. The proposed classification is investigated by using 5%-damped response spectra from Italian earthquake records. We select a dataset of 602 three-component analog and digital recordings from 120 earthquakes recorded at 214 seismic stations within a hypocentral distance of 200 km. Selected events are in the momentmagnitude range 4:0 d Mw d 6:8 and focal depths from a few kilometers to 46 km. We computed H/V ratios for these data and used them to classify each site into one of six classes. We then investigate the impact of this classification scheme on empirical ground-motion prediction equations (GMPEs) by comparing its performance with that of the conventional rock/soil classification. Although the adopted approach results in only a small reduction of the overall standard deviation, the use of H/V spectral ratios in site classification does capture the signature of sites with flat frequency-response, as well as deep and shallow-soil profiles, characterized by long- and short-period resonance, respectively; in addition, the classification scheme is relatively quick and inexpensive, which is an advantage over schemes based on measurements of shearwave velocity.