The Tsangpo-Brahmaputra River drains the eastern part of the Himalayan range and flows from the Tibetan Plateau through the eastern Himalayan syntaxis downstream to the Indo-Gangetic floodplain and the Bay of Bengal. As such, it is a unique natural laboratory to study how denudation and sediment production processes are transferred to river detrital signals. In this study, we present a new Be-10 data set to constrain denudation rates across the catchment and to quantify the impact of rapid erosion within the syntaxis region on cosmogenic nuclide budgets and signals. The measured Be-10 denudation rates span around 2 orders of magnitude across individual catchments (ranging from 0.03 to > 4 mm yr(-1)) and sharply increase as the Tsangpo-Brahmaputra flows across the eastern Himalaya. The increase in denudation rates, however, occurs similar to 150 km downstream of the Namche Barwa-Gyala Peri massif (NBGPm), an area which has been previously characterized by extremely high erosion and exhumation rates. We suggest that this downstream lag is mainly due to the physical abrasion of coarse-grained, low Be-10 concentration, landslide material produced within the syntaxis that dilutes the upstream high-concentration Be-10 flux from the Tibetan Plateau only after abrasion has transferred sediment to the studied sand fraction. A simple abrasion model produces typical lag distances of 50 to 150 km compatible with our observations. Abrasion effects reduce the spatial resolution over which denudation can be constrained in the eastern Himalayan syntaxis. In addition, we also highlight that denudation rate estimates are dependent on the sediment connectivity, storage, and quartz content of the upstream Tibetan Plateau part of the catchment, which tends to lead to an overestimation of downstream denudation rates. While no direct Be-10 denudation measurements were made in the syntaxis, the dilution of the upstream Be-10 signal, measured in Tsangpo-Brahmaputra sediments, provides constraints on the denudation rates in that region. These denudation estimates range from ca. 2 to 5 mm yr(-1) for the entire syntaxis and ca. 4 to 28 mm yr(-1) for the NBGPm, which is significantly higher than other large catchments. Overall, Be-10 concentrations measured at the outlet of the Tsangpo-Brahmaputra in Bangladesh suggest a sediment flux between 780 and 1430 Mt yr(-1) equivalent to a denudation rate between 0.7 and 1.2 mm yr(-1) for the entire catchment.