A process based on extrusion coupled with supercritical carbon dioxide (scCO2) was implemented. ScCO2 modifies the rheological properties of the material in the barrel of the extruder and acts as a blowing agent during the relaxation at the passage through the die. An experimental device based on a single-screw extruder allows the injection of scCO2 into the melt, the mixing of both components and the creation of porosity into the extruded polymer. In this work, it was used to produce foams of polyhydroxybutyrate-hydroxyvalerate (PHB-HV), a semi-crystalline biodegradable and biocompatible copolymer. The effects on material porosity of the melt temperature before the die and the die temperature were studied