The Axon Initial Segment: An Updated Viewpoint - Archive ouverte HAL Access content directly
Journal Articles Journal of Neuroscience Year : 2018

The Axon Initial Segment: An Updated Viewpoint

Abstract

At the base of axons sits a unique compartment called the axon initial segment (AIS). The AIS generates and shapes the action potential before it is propagated along the axon. Neuronal excitability thus depends crucially on the AIS composition and position, and these adapt to developmental and physiological conditions. The AIS also demarcates the boundary between the somatodendritic and axonal compartments. Recent studies have brought insights into the molecular architecture of the AIS and how it regulates protein trafficking. This Viewpoints article summarizes current knowledge about the AIS and highlights future challenges in understanding this key actor of neuronal physiology.

Domains

Neurobiology
Fichier principal
Vignette du fichier
2018_J Neurosci_Leterrier.pdf (2.02 Mo) Télécharger le fichier
Origin : Explicit agreement for this submission
Loading...

Dates and versions

hal-01736917 , version 1 (20-04-2018)

Identifiers

Cite

Christophe Leterrier. The Axon Initial Segment: An Updated Viewpoint. Journal of Neuroscience, 2018, 38 (9), pp.2135-2145. ⟨10.1523/JNEUROSCI.1922-17.2018⟩. ⟨hal-01736917⟩
81 View
218 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More